Bergfeldt L, Möller E
Tissue Antigens. 1983 May;21(5):385-90. doi: 10.1111/j.1399-0039.1983.tb00188.x.
An increased prevalence of ankylosing spondylitis and other HLA B27-associated rheumatic diseases has recently been demonstrated in a group of men with permanent pacemaker-treatment. The purpose of the present study was to find out if HLA B27 was associated with severe bradyarrhythmias also in the absence of rheumatic disease. The frequency of B27 was determined in 83 permanently paced men with complete heart block, in whom presence of radiological or clinical signs of a B27-associated rheumatic disease had been excluded. Eighty-four healthy subjects were HLA typed for comparison. HLA B27 was found in 17% of the patients and in 6% of the controls, a significant difference with P = 0.017 (Fisher's exact test). The present study suggests that, in a subgroup of patients with complete heart block, the development of heart block is B27-associated, and that the pathophysiological mechanism is similar to that leading to ankylosing spondylitis. Another B27-associated disease manifestation has been demonstrated.
最近在一组接受永久起搏器治疗的男性中，强直性脊柱炎和其他与HLA B27相关的风湿性疾病的患病率有所增加。本研究的目的是查明在没有风湿性疾病的情况下，HLA B27是否也与严重心律失常有关。测定了83名患有完全性心脏传导阻滞的永久起搏男性的B27频率，这些男性已排除了与B27相关的风湿性疾病的放射学或临床体征。选取84名健康受试者进行HLA分型作为对照。在17%的患者和6%的对照中发现了HLA B27，差异有统计学意义（P = 0.017，Fisher精确检验）。本研究表明，在一组完全性心脏传导阻滞患者中，心脏传导阻滞的发生与B27相关，且病理生理机制与导致强直性脊柱炎的机制相似。已证实了另一种与B27相关的疾病表现。
