二氮杂磷烯催化的多氟芳烃与苯硅烷协同亲核芳香取代的氢氟化反应。
Diazaphospholene-Catalyzed Hydrodefluorination of Polyfluoroarenes with Phenylsilane via Concerted Nucleophilic Aromatic Substitution.
机构信息
Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing 100084, China.
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
J Org Chem. 2022 Jan 7;87(1):294-300. doi: 10.1021/acs.joc.1c02360. Epub 2021 Dec 21.
PMID:34933552
Abstract
The metal-free catalytic C-F bond activation of polyfluoroarenes was achieved with diazaphospholene as the catalyst and phenylsilane as the terminal reductant. Density functional theory calculations suggested a concerted nucleophilic aromatic substitution mechanism.
摘要
实现了多氟芳烃的无金属催化 C-F 键活化，使用二氮杂磷烯作为催化剂，苯硅烷作为末端还原剂。密度泛函理论计算表明存在协同亲核芳香取代机理。
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