1 型糖尿病合并注意力缺陷多动障碍成人的血糖控制与糖尿病相关并发症。
Glycemic Control and Diabetes Related Complications in Adults with Type 1 Diabetes Mellitus and ADHD.
机构信息
Assuta Ashdod University Hospital, Israel.
Tel Aviv Sourasky Medical Center, Israel.
出版信息
J Atten Disord. 2022 Jul;26(9):1235-1244. doi: 10.1177/10870547211068039. Epub 2021 Dec 21.
OBJECTIVE
To assess the correlation of co-morbid ADHD and diabetes-related complications in patients with type-1-diabetes-mellitus (T1DM).
METHODS
A retrospective cross-sectional study was conducted during 2018 using the Leumit-Health-Services(LHS) database. Diabetes-related complications were assessed in patients with T1DM and ADHD (T1DM-ADHD+) and compared with patients with T1DM alone (T1DM-ADHD-).
RESULTS
Out of 789 adult-patients with T1DM, 75 (9.5%) were T1DM-ADHD+, matched to 225 T1DM-ADHD-. HbAC levels were higher in T1DM-ADHD+ patients (8.1% ± 1.6 vs. 7.4% ± 1.2, < .01), as well as diabetes-related complications: neuropathy (22.7% vs. 5.8%, < .01), ulcers (8% vs. 0.9%, < .05), limb amputation (5.3% vs. 0.9%, < .05), albuminuria (15.5% vs. 2.8%, < .01), chronic renal failure (10.6% vs. 2.5%, = .01), and emergency room admissions rate (26.7% vs. 15.1%, < .05). In sub-analysis, lower average HbAC levels and diabetic ulcer rates were found among ADHD patients treated with stimulants, all < .05.
CONCLUSION
Co-morbidity of ADHD and T1DM is associated with poor glycemic control and higher complication rates.
目的
评估患有 1 型糖尿病（T1DM）的患者共患注意力缺陷多动障碍（ADHD）与糖尿病相关并发症的相关性。
方法
2018 年，我们进行了一项回顾性的横断面研究，使用 Leumit-Health-Services（LHS）数据库。在患有 T1DM 和 ADHD（T1DM-ADHD+）的患者中评估糖尿病相关并发症，并与仅患有 T1DM 的患者（T1DM-ADHD-）进行比较。
结果
在 789 名成年 T1DM 患者中，75 名（9.5%）为 T1DM-ADHD+，与 225 名 T1DM-ADHD-患者相匹配。T1DM-ADHD+患者的 HbAC 水平更高（8.1%±1.6 与 7.4%±1.2， < .01），且糖尿病相关并发症的发生率也更高：神经病变（22.7%与 5.8%， < .01）、溃疡（8%与 0.9%， < .05）、肢体截肢（5.3%与 0.9%， < .05）、白蛋白尿（15.5%与 2.8%， < .01）、慢性肾衰竭（10.6%与 2.5%， = .01）和急诊入院率（26.7%与 15.1%， < .05）。在亚分析中，我们发现接受兴奋剂治疗的 ADHD 患者的平均 HbAC 水平和糖尿病溃疡发生率较低，均 < .05。
结论
ADHD 与 T1DM 共病与血糖控制不佳和更高的并发症发生率相关。
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