Xie Xue-Ni, Lei Xue, Xiao Chun-Ye, Li Ya-Min, Lei Xian-Yang
Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, China.
School of Public Health, Kunming Medical University, Kunming, China.
Front Psychiatry. 2022 Nov 22;13:982696. doi: 10.3389/fpsyt.2022.982696. eCollection 2022.
Type 1 diabetes and neurodevelopmental disorders are common chronic conditions in childhood and adolescence, and having one may lead to an increased chance of developing the other. Type 1 diabetes mellitus is mainly manifested by elevated blood glucose, while neurodevelopmental diseases are composed of a variety of diseases, which are relatively complex. The purpose of this meta-analysis was to find out the prevalence of type 1 diabetes-related neurodevelopmental disorders in children and adolescents and to explore the potential association between neurodevelopmental disorders and type 1 diabetes. PubMed, Embase and Web of science databases were searched from the inception to May 22, 2022 to identify relevant studies, Finally, 24 original studies were included in the meta-analysis. Prevalence estimates for neurodevelopmental disorders in the type 1 diabetes adolescent and their 95% confidence intervals were pooled using random effects models. The pooled estimates for autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) in the type 1 diabetes population were 1.2 and 5.3%, respectively, both of which are higher than the 2019 global prevalence of ASD and ADHD in the general population. The results of the subgroup analysis showed that the prevalence of ASD and ADHD in the T1DM population tended to increase with age. In conclusion, there may be a potential link between the occurrence of type 1 diabetes mellitus and the development of neurodevelopmental disorders in children and adolescents, but more relevant studies are needed to understand the link between the underlying pathogenesis of type 1 diabetes and neurodevelopmental disorders.
[https://www.crd.york.ac.uk/PROSPERO/], identifier [CDR42022333443].
1型糖尿病和神经发育障碍是儿童和青少年常见的慢性疾病，患有一种疾病可能会增加患另一种疾病的几率。1型糖尿病主要表现为血糖升高，而神经发育疾病由多种疾病组成，相对复杂。本荟萃分析的目的是找出儿童和青少年中与1型糖尿病相关的神经发育障碍的患病率，并探讨神经发育障碍与1型糖尿病之间的潜在关联。检索了PubMed、Embase和Web of science数据库从创建到2022年5月22日的相关研究，最终，24项原始研究被纳入荟萃分析。使用随机效应模型汇总了1型糖尿病青少年中神经发育障碍的患病率估计值及其95%置信区间。1型糖尿病人群中自闭症谱系障碍（ASD）和注意力缺陷多动障碍（ADHD）的汇总估计值分别为1.2%和5.3%，均高于2019年全球普通人群中ASD和ADHD的患病率。亚组分析结果显示，1型糖尿病患者中ASD和ADHD的患病率随年龄增长有上升趋势。总之，1型糖尿病的发生与儿童和青少年神经发育障碍的发展之间可能存在潜在联系，但需要更多相关研究来了解1型糖尿病潜在发病机制与神经发育障碍之间的联系。
