Department of Pharmacy, College of Pharmacy and Health care, Tajen University, Pingtung, Taiwan.
Departments of Emergency and Critical Care Medicine, Min-Sheng General Hospital, Taoyuan, Taiwan.
Expert Rev Anti Infect Ther. 2022 Jun;20(6):941-953. doi: 10.1080/14787210.2022.2021876. Epub 2022 Jan 11.
To determine the activities of novel and comparator antibiotics against Gram-negative bacteria (GNB) in Taiwan.
Isolates of (n = 335), (n = 316; 144 isolates with hyperviscosity characteristics), (n = 271), complex (n = 187), and non-typhoidal species (n = 226), species (n = 13) from miscellaneous culture sources were collected in 2020 in Taiwan. The MICs of the isolates to test antibiotics were determined using the broth microdilution method. GeneXpert was used to detect genes encoding carbapenemases among the carbapenem-non-susceptible (NS) isolates.
The MIC values of the cefepime-enmetazobactam combination against extended-spectrum β-lactamase-producing and isolates (MIC ≤ 0.5 mg/L), -harboring isolates (0.25 mg/L; n = 2), and 80% of -like gene-harboring isolates (≤2 mg/L) were low. The MIC ranges of the cefepime-zidebactam against carbapenemase-producing isolates (irrespective of the carbapenemase type [MIC ≤ 4 mg/L]) and carbapenem-NS or ceftolozane-tazobactam-NS isolates (MIC value, 8 mg/L) were significantly lower than those of the cefepime-enmetazobactam.
The efficacy of novel antibiotics against important drug-resistant GNB must be monitored and validated during the clinical treatment of patients.
确定新型和对照抗生素对台湾革兰氏阴性菌（GNB）的活性。
2020 年在台湾收集了（n=335）、（n=316；144 株具有高粘性特征）、（n=271）、复杂（n=187）和非伤寒沙门氏菌（n=226）、（n=13）种来自各种培养源的分离株。使用肉汤微量稀释法测定分离株对抗生素的 MIC。使用 GeneXpert 检测耐碳青霉烯（NS）的分离株中编码碳青霉烯酶的基因。
头孢吡肟-依马替尼联合用药对产超广谱β-内酰胺酶的和分离株（MIC≤0.5mg/L）、携带基因的分离株（0.25mg/L；n=2）和 80%携带基因的类似物分离株（≤2mg/L）的 MIC 值较低。头孢吡肟-齐多夫坦对产碳青霉烯酶的分离株（不论碳青霉烯酶类型[MIC≤4mg/L]）和耐碳青霉烯或头孢他啶-他唑巴坦 NS 的分离株（MIC 值为 8mg/L）的 MIC 范围明显低于头孢吡肟-依马替尼。
新型抗生素对重要耐药性 GNB 的疗效必须在患者的临床治疗中进行监测和验证。
