Al Kamaly Omkulthom
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Int J Anal Chem. 2022 Jun 29;2022:6909528. doi: 10.1155/2022/6909528. eCollection 2022.
Infection is one of the most important reasons for the increase in the number of deaths worldwide; it can be a bacterial or viral infection. As a result, there are many effective drugs against this infection, especially bacterial ones. Cefepime (CP) is one of the fourth generations of cephalosporins and is distinguished from others in that it can kill both positive and negative bacteria. Therefore, this study focused on the chemical properties of the drug, its uses, and its stability against bacteria. All analysis methods for this drug in pharmaceutical preparations, blood, or plasma were also presented. One of the important problems in these methods is using toxic solvents, which poses a danger to society and the environment. The presentation of these solvents will allow companies to manufacture and use more effective and less toxic solvents.
感染是全球死亡人数增加的最重要原因之一；它可以是细菌感染或病毒感染。因此，有许多针对这种感染的有效药物，尤其是针对细菌感染的药物。头孢吡肟（CP）是第四代头孢菌素之一，与其他头孢菌素的区别在于它既能杀死阳性菌又能杀死阴性菌。因此，本研究聚焦于该药物的化学性质、用途及其对细菌的稳定性。还介绍了该药物在药物制剂、血液或血浆中的所有分析方法。这些方法中的一个重要问题是使用有毒溶剂，这对社会和环境构成危险。介绍这些溶剂将使公司能够生产和使用更有效且毒性更小的溶剂。
