Zhou Shujuan, Fang Fang, Chen Huiyao, Zhang Wei, Chen Yang, Shi Yifen, Zheng Zhouyi, Ma Yongyong, Tang Liyuan, Feng Jianhua, Zhang Yu, Sun Lan, Chen Yi, Liang Bin, Yu Kang, Jiang Songfu
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.
Department of Hematology and Oncology, Tranditional Chinese Medical Hospital of Zhuji, Zhejiang, P.R. China.
Oncotarget. 2017 Jun 20;8(25):40724-40731. doi: 10.18632/oncotarget.16560.
This study examined the prognostic value of the baseline red blood cell distribution width (RDW) in diffuse large B cell lymphoma (DLBCL) patients. The associations between RDW and clinical characteristics were assessed in 161 DLBCL patients from 2005 to 2016. The log-rank test, univariate analysis, and Cox regression analysis were used to evaluate the relationship between RDW and survival. A RDW of 14.1% was considered to be the optimal cut-off value for predicting prognosis. A high RDW was associated with more frequent B symptoms (P=0.001), a higher International Prognostic Index score (P=0.032), more extranodal sites of disease (P=0.035), and significantly lower Eastern Cooperative Oncology Group performance status (P=0.031). The log-rank test demonstrated that patients with a high RDW had a shorter overall survival (OS) (2-year OS rate, 53.6% vs. 83.6%, P<0.001) and progression-free survival (PFS) (2-year PFS rate, 44.7% vs. 81.8%, P<0.001). The multivariate analysis demonstrated that RDW ≥14.1% was an independent predictor of OS (odds ratio [OR] = 0.345, P<0.001) and PFS (OR = 0.393, P=0.001). We demonstrated that a high RDW predicted an unfavorable prognosis in patients with DLBCL.
本研究探讨了基线红细胞分布宽度（RDW）在弥漫性大B细胞淋巴瘤（DLBCL）患者中的预后价值。在2005年至2016年期间纳入的161例DLBCL患者中评估了RDW与临床特征之间的关联。采用对数秩检验、单因素分析和Cox回归分析来评估RDW与生存之间的关系。将RDW为14.1%视为预测预后的最佳临界值。高RDW与更频繁的B症状（P=0.001）、更高的国际预后指数评分（P=0.032）、更多的结外病变部位（P=0.035）以及显著更低的东部肿瘤协作组体能状态（P=0.031）相关。对数秩检验表明，RDW高的患者总生存期（OS）较短（2年OS率，53.6%对83.6%，P<0.001）和无进展生存期（PFS）较短（2年PFS率，44.7%对81.8%，P<0.001）。多因素分析表明，RDW≥14.1%是OS（比值比[OR]=0.345，P<0.001）和PFS（OR=0.393，P=0.001）的独立预测因素。我们证明，高RDW预示着DLBCL患者预后不良。
