作为生殖调节整合中心的 kisspeptin 神经元：基于生殖调节神经系统新概念对生殖功能的观察
Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system.
作者信息
Ozawa Hitoshi
机构信息
Department of Anatomy and Neurobiology Graduate School of Medicine Nippon Medical School Tokyo Japan.
出版信息
Reprod Med Biol. 2021 Oct 7;21(1):e12419. doi: 10.1002/rmb2.12419. eCollection 2022 Jan.
Abstract
BACKGROUND
Regulation of the reproductive system has been explained by the actions and feedback of gonadotropin releasing hormone-luteinizing hormone/follicle stimulating hormone (GnRH-LH/FSH) -sex steroids; however, the discovery of kisspeptin neurons and a kisspeptin-GnRH-LH/FSH axis has prompted this regulation to be reviewed.
METHODS
We investigated changes in kisspeptin neurons and associated changes in the hypothalamic-pituitary-gonadal (HPG) axis under various situations and experimental conditions using histochemical methods.
MAIN FINDINGS RESULTS
Kisspeptin neurons play an important role in receiving and integrating information from internal and external environmental factors and communicating it to the conventional HPG axis.
CONCLUSION
The recently described Kisspeptin-GnRH-LH/FSH-gonad system regulates reproductive function via mechanisms that until recently were not completely understood.
摘要
背景
生殖系统的调节一直通过促性腺激素释放激素 - 黄体生成素/卵泡刺激素（GnRH - LH/FSH） - 性类固醇的作用和反馈来解释；然而，亲吻素神经元以及亲吻素 - GnRH - LH/FSH轴的发现促使人们对这种调节进行重新审视。
方法
我们使用组织化学方法研究了在各种情况和实验条件下亲吻素神经元的变化以及下丘脑 - 垂体 - 性腺（HPG）轴的相关变化。
主要发现结果
亲吻素神经元在接收和整合来自内部和外部环境因素的信息并将其传递给传统HPG轴方面发挥着重要作用。
结论
最近描述的亲吻素 - GnRH - LH/FSH - 性腺系统通过直到最近还未被完全理解的机制调节生殖功能。
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