Sharma Pranjali, Eigbire George, Sharma Rutwik
Endocrinology, Parkview Medical Center, Pueblo, USA.
Cardiology, Louisiana State University Health Sciences Center, New Orleans, USA.
Cureus. 2021 Nov 18;13(11):e19705. doi: 10.7759/cureus.19705. eCollection 2021 Nov.
Urachal adenocarcinoma is a rare but highly malignant epithelial cancer that accounts for <1% of all bladder malignancies and commonly presents with hematuria. We report a case of metastatic urachal adenocarcinoma presenting as bowel obstruction. A 54-year-old male patient with a history of alcohol abuse presented to the emergency with acute-onset, diffuse, cramping abdominal pain, worst in the epigastrium and lasting one day. Abdominal examination revealed moderate guarding and generalized tenderness with hypoactive bowel sounds. Imaging confirmed an evolving small bowel obstruction and a urachal remnant with a superimposed mass lesion. The patient underwent an exploratory laparotomy and a high-grade small bowel obstruction due to the mass was identified. An intraoperative frozen section identified adenocarcinoma. A biopsy of the urachal mass confirmed urachal adenocarcinoma. The final diagnosis was moderately differentiated urachal adenocarcinoma. The tumor was deemed unresectable due to the involvement of multiple loops of the small bowel and the mesentery of the small and large bowels. Systemic chemotherapy with 5-fluorouracil (5-FU), leucovorin, and oxaliplatin (modified FOLFOX-6) was initiated. Our patient did not report any prior urinary symptoms or recurrent abdominal pain, which are the common symptoms that urachal adenocarcinoma presents with. Bowel obstruction is a rare presentation of urachal adenocarcinoma since the spread of the disease to the viscera occurs much later in the course. This case report highlights a rare presentation of an even rarer malignancy.
脐尿管腺癌是一种罕见但高度恶性的上皮性癌,占所有膀胱恶性肿瘤的比例不到1%,通常表现为血尿。我们报告一例以肠梗阻为表现的转移性脐尿管腺癌病例。一名有酗酒史的54岁男性患者因急性发作的弥漫性绞痛性腹痛到急诊就诊,上腹部疼痛最为严重,持续一天。腹部检查发现有中度肌紧张和广泛性压痛,肠鸣音减弱。影像学检查证实存在进展性小肠梗阻以及脐尿管残余伴叠加的肿块病变。患者接受了剖腹探查术,术中发现因肿块导致高位小肠梗阻。术中冰冻切片检查确诊为腺癌。脐尿管肿块活检证实为脐尿管腺癌。最终诊断为中度分化的脐尿管腺癌。由于小肠多个肠袢以及小肠和大肠系膜受累,该肿瘤被认为无法切除。遂开始采用5-氟尿嘧啶(5-FU)、亚叶酸钙和奥沙利铂(改良FOLFOX-6方案)进行全身化疗。我们的患者既往未报告任何常见的脐尿管腺癌症状,如泌尿系统症状或反复腹痛。肠梗阻是脐尿管腺癌罕见的表现形式,因为该疾病向内脏扩散在病程中发生得要晚得多。本病例报告突出了一种极为罕见的恶性肿瘤的罕见表现形式。