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囊胚期冻融胚胎移植后与卵裂期后异位/子宫外妊娠的发生率：辅助生殖技术协会临床结果报告系统研究

The incidence of ectopic/heterotopic pregnancies after blastocyst-stage frozen-thawed embryo transfers compared with that after cleavage-stage: a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study.

作者信息

Krishnamoorthy Kavitha, Greenberg Patricia, Perlman Barry E, Morelli Sara S, Jindal Sangita K, McGovern Peter G

机构信息

Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey.

Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey.

出版信息

F S Rep. 2021 Jul 3;2(4):421-427. doi: 10.1016/j.xfre.2021.06.010. eCollection 2021 Dec.

DOI:10.1016/j.xfre.2021.06.010
PMID:34934982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8655396/
Abstract

OBJECTIVE

To investigate whether there is a difference in the ectopic/heterotopic pregnancy rate of blastocyst-stage frozen-thawed embryo transfers (FETs) compared with that of cleavage-stage FETs.

DESIGN

A retrospective cohort study.

SETTING

Not applicable.

PATIENTS

Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619), as reported to the Society for Assisted Reproductive Technology from 2004 to 2013.

INTERVENTIONS

None.

MAIN OUTCOME MEASURES

Pregnancy outcomes, specifically ectopic pregnancy rates and heterotopic pregnancy rates.

RESULTS

Among those who became pregnant, there was a significantly lower incidence of ectopic/heterotopic pregnancies in blastocyst-stage FETs versus that in cleavage-stage FETs (0.8% vs. 1.1%). The differences in ectopic/heterotopic pregnancy rates remained statistically significant after controlling for confounders such as tubal factor infertility and number of embryos transferred.

CONCLUSIONS

Blastocyst-stage FET was associated with a lower ectopic/heterotopic pregnancy rate compared with cleavage-stage FET.

摘要

目的

探讨囊胚期冻融胚胎移植（FET）与卵裂期FET相比，异位/异期妊娠率是否存在差异。

设计

一项回顾性队列研究。

地点

不适用。

患者

2004年至2013年向辅助生殖技术协会报告的接受自体FET的女性，其中囊胚期（n = 118,572）或卵裂期（n = 117,619）。

干预措施

无。

主要观察指标

妊娠结局，特别是异位妊娠率和异期妊娠率。

结果

在怀孕的女性中，囊胚期FET的异位/异期妊娠发生率明显低于卵裂期FET（0.8%对1.1%）。在控制了诸如输卵管因素不孕和移植胚胎数量等混杂因素后，异位/异期妊娠率的差异仍具有统计学意义。

结论

与卵裂期FET相比，囊胚期FET与较低的异位/异期妊娠率相关。

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Medicina (Kaunas). 2020 Nov 30;56(12):665. doi: 10.3390/medicina56120665.
2
Tubal infertility and pelvic adhesion increase risk of heterotopic pregnancy after in vitro fertilization: A retrospective study.输卵管性不孕和盆腔粘连增加体外受精后异位妊娠风险：一项回顾性研究。
Medicine (Baltimore). 2020 Nov 13;99(46):e23250. doi: 10.1097/MD.0000000000023250.
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Investigating the impact of the timing of blastulation on implantation: management of embryo-endometrial synchrony improves outcomes.
输卵管切除术对有宫外孕病史患者在体外受精/卵胞浆内单精子注射后宫外孕风险及特征的影响：一项大型回顾性队列研究。
Acta Obstet Gynecol Scand. 2025 Apr;104(4):720-728. doi: 10.1111/aogs.15059. Epub 2025 Jan 27.
4
Atosiban application in fresh ET cycle is effective for women undergoing repeated embryo implantation failures, especially for advanced-age obese patients.阿托西班在新鲜周期 ET 中应用对于反复胚胎种植失败的患者有效，尤其是高龄肥胖患者。
Sci Rep. 2023 Dec 27;13(1):23044. doi: 10.1038/s41598-023-49773-z.
5
Is timing everything? Risk of ectopic pregnancy in day 3 versus day 5 transfer.时机决定一切吗？第3天与第5天胚胎移植的异位妊娠风险
F S Rep. 2021 Sep 7;2(4):370-371. doi: 10.1016/j.xfre.2021.08.013. eCollection 2021 Dec.
研究囊胚形成时间对着床的影响：管理胚胎与子宫内膜同步性可改善结局。
Hum Reprod Open. 2018 Dec 20;2018(4):hoy022. doi: 10.1093/hropen/hoy022. eCollection 2018.
4
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Fertil Steril. 2018 Jul 1;110(1):89-94.e2. doi: 10.1016/j.fertnstert.2018.03.033. Epub 2018 Jun 13.
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MMWR Surveill Summ. 2017 Feb 10;66(6):1-24. doi: 10.15585/mmwr.ss6606a1.
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