Crampton J R, Gibbons L C, Rees W D
Scand J Gastroenterol Suppl. 1986;125:113-8. doi: 10.3109/00365528609093826.
The effect of luminal application of aluminum sulphate, sucralfate, and bismuth subcitrate on gastroduodenal alkali secretion has been studied with isolated amphibian mucosa. The mucosa, stripped of its external muscle layer, was mounted in chambers that allowed titration of alkali secretion and measurement of transmucosal potential difference and electrical resistance. Neutral aluminum sulphate (3 X 10(-3) M) increased bicarbonate secretion by fundic (mean +/- SEM = 144 +/- 48%, n = 5, P less than 0.05), antral (mean +/- SEM = 214 +/- 63%, n = 4, P less than 0.05), and duodenal (mean +/- SEM = 133 +/- 44%, n = 6, P less than 0.005) mucosa. Sucralfate (0.5 g/l) stimulated fundic (mean +/- SEM = 183 +/- 87%, n = 4, P less than 0.05) and antral (mean +/- SEM = 156 +/- 58%, n = 5, P less than 0.005) alkali secretion and, at a concentration of 1 g/l, duodenal output (mean +/- SEM = 42 +/- 15%, n = 6, P less than 0.05). Bismuth subcitrate (10(-4) M) produced a significant rise in fundic (mean +/- SEM = 80 +/- 21%, n = 5, P less than 0.05) and duodenal (mean +/- SEM = 62 +/- 7%, n = 6, P less than 0.05) alkali secretion. None of these agents altered transmucosal potential difference or electrical resistance. The actions of these agents on gastroduodenal bicarbonate secretion may be important in their ulcer healing effects.
已使用离体两栖类动物黏膜研究了腔内应用硫酸铝、硫糖铝和枸橼酸铋对胃十二指肠碱分泌的影响。去除外层肌肉层的黏膜被安装在可滴定碱分泌并测量跨黏膜电位差和电阻的腔室中。中性硫酸铝（3×10⁻³M）可使胃底（平均值±标准误=144±48%，n=5，P<0.05）、胃窦（平均值±标准误=214±63%，n=4，P<0.05）和十二指肠（平均值±标准误=133±44%，n=6，P<0.005）黏膜的碳酸氢盐分泌增加。硫糖铝（0.5g/l）刺激胃底（平均值±标准误=183±87%，n=4，P<0.05）和胃窦（平均值±标准误=156±58%，n=5，P<0.005）的碱分泌，在浓度为1g/l时，刺激十二指肠分泌（平均值±标准误=42±15%，n=6，P<0.05）。枸橼酸铋（10⁻⁴M）使胃底（平均值±标准误=80±21%，n=5，P<0.05）和十二指肠（平均值±标准误=62±7%，n=6，P<0.05）的碱分泌显著增加。这些药物均未改变跨黏膜电位差或电阻。这些药物对胃十二指肠碳酸氢盐分泌的作用可能在其溃疡愈合作用中很重要。
