Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
J Med Virol. 2022 May;94(5):1815-1820. doi: 10.1002/jmv.27539. Epub 2021 Dec 31.
The polybasic furin cleavage site insertion with four amino acid motifs (PRRA) in spike protein's S1/S2 junction site is important in determining viral infectivity, transmission, and host range. However, there is no review so far explaining the effect of the furin cleavage site of the spike protein on SARS-CoV-2 replication and pathogenesis in the host and immune responses and vaccination. Therefore, here we specifically focused on genomic evolution and properties of the cleavage site of spike protein in the context of SARS-CoV-2 followed by its effect on viral entry, replication, and pathogenesis. We also explored whether the spike protein furin cleavage site affected the host immune responses and SARS-CoV-2 vaccination. This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID-19 pandemic.
多碱性弗林蛋白酶裂解位点在刺突蛋白 S1/S2 连接处插入四个氨基酸序列（PRRA），对于确定病毒的感染力、传播性和宿主范围非常重要。然而，迄今为止，尚无文献综述解释弗林蛋白酶裂解位点对 SARS-CoV-2 在宿主和免疫反应及疫苗接种中的复制和发病机制的影响。因此，在这里我们特别关注 SARS-CoV-2 中刺突蛋白裂解位点的基因组进化和特性，以及其对病毒进入、复制和发病机制的影响。我们还探讨了刺突蛋白弗林蛋白酶裂解位点是否影响宿主的免疫反应和 SARS-CoV-2 疫苗接种。这篇综述将有助于深入了解多碱性弗林蛋白酶裂解位点对当前 COVID-19 大流行的影响。
