Divisão de Vigilância em Saúde, 17a Regional de Saúde, Secretaria de Estado da Saúde do Paraná, Londrina, Brazil.
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Mycoses. 2022 Mar;65(3):354-361. doi: 10.1111/myc.13417. Epub 2022 Jan 3.
Paracoccidioidomycosis, caused by fungi of the Paracoccidioides genus, is one of the most important endemic mycoses in Brazil. The disease is not of mandatory reporting in the country; however, some Brazilian states, such as Paraná, have included it on their local lists of public health-reportable diseases.
Describe the epidemiology of the positive paracoccidioidomycosis cases in the state of Paraná based on analysis of reporting forms and mortality data.
Data of positive cases of state residents 2007-2020 were obtained from public health databases and frequency, incidence, geographic distribution, mortality and trends were analysed. Mortality of the disease was also compared to other mycoses such as cryptococcosis, aspergillosis, histoplasmosis, candidiasis and sporotrichosis.
670 patients were positive for the disease. The cumulative and average annual incidence was, respectively, 6.4 and 0.46 cases/100,000 inhabitants. The new cases of paracoccidioidomycosis were reported mainly by specialised health units, including tertiary centres, and 285 days was the mean from the beginning of the symptoms until the diagnosis. The western region showed the highest incidence and mortality by the disease over the other state mesoregions. During the period, a decreasing trend was observed in the confirmed cases and stability in the mortality rate with an average annual mortality of 1.17 per million/inhabitants in the state; however, paracoccidioidomycosis had the highest mortality when compared to other mycoses.
Paracoccidioidomycosis is an important endemic mycosis in Paraná and this study provides an epidemiological baseline for future modifications of paracoccidioidomycosis surveillance.
由副球孢子菌属真菌引起的副球孢子菌病是巴西最重要的地方性真菌病之一。该疾病在该国并非强制报告疾病；然而，一些巴西州，如巴拉那州，已将其纳入地方公共卫生报告疾病清单。
根据报告表格和死亡率数据，描述巴西南里奥格兰德州副球孢子菌病阳性病例的流行病学情况。
从公共卫生数据库中获取 2007-2020 年巴西南里奥格兰德州居民的阳性病例数据，并对频率、发病率、地理分布、死亡率和趋势进行分析。还将该疾病的死亡率与其他真菌病（如隐球菌病、曲霉病、组织胞浆菌病、念珠菌病和孢子丝菌病）进行了比较。
670 例患者的疾病检测呈阳性。累积和平均年发病率分别为 6.4 和 0.46 例/100,000 居民。副球孢子菌病的新发病例主要由专门的卫生单位报告，包括三级中心，从症状开始到诊断的平均时间为 285 天。与该州其他地区相比，西部地区的发病率和死亡率最高。在此期间，确诊病例呈下降趋势，死亡率保持稳定，该州的年平均死亡率为每百万居民 1.17 人；然而，与其他真菌病相比，副球孢子菌病的死亡率最高。
副球孢子菌病是巴西南里奥格兰德州的一种重要地方性真菌病，本研究为未来副球孢子菌病监测的修改提供了流行病学基线。
