Li H S, Luo G X, Yuan Z Q
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.
Zhonghua Shao Shang Za Zhi. 2021 Dec 20;37(12):1199-1204. doi: 10.3760/cma.j.cn501120-20200828-00396.
The progressive deepening of burn wounds is one of the common clinical problems and difficulties in early burn treatment. At the present, it is believed that local ischemia and hypoxia, persistent inflammation, infection, unbalanced local microenvironment, cell necrosis, apoptosis, and autophagy are the main mechanisms of progressive deepening of burn wounds. In recent years, basic and clinical studies have proposed various new strategies for prevention and treatment of progressive deepening of burn wounds, mainly including correct cooling, improving blood perfusion of the wound, early debridement, improving the wound microenvironment, preventing and treating wound infection, reducing wound inflammation, and inhibiting the oxidative stress in the wound. This review focuses on the current progress of prevention and treatment strategies of burn wound progressive deepening, in order to provide references for the treatment of burn wounds.
烧伤创面进行性加深是烧伤早期治疗中常见的临床问题和难点之一。目前认为，局部缺血缺氧、持续炎症反应、感染、局部微环境失衡、细胞坏死、凋亡及自噬是烧伤创面进行性加深的主要机制。近年来，基础与临床研究提出了多种防治烧伤创面进行性加深的新策略，主要包括正确冷疗、改善创面血液灌注、早期清创、改善创面微环境、防治创面感染、减轻创面炎症反应以及抑制创面氧化应激等。本文综述了烧伤创面进行性加深防治策略的研究现状，以期为烧伤创面的治疗提供参考。
