Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Ophthalmol. 2022 Jan;70(1):189-193. doi: 10.4103/ijo.IJO_1125_21.
To compare the anatomical and refractive outcomes of transscleral diode versus transpupillary laser photocoagulation for the treatment of zone II type 1 retinopathy of prematurity (ROP).
In this prospective comparative interventional case series, infants with type 1 ROP in zone II were assigned to either transpupillary or transscleral laser based on the surgeons' expertise area. The rate of regression, need for retreatment, and structural and biometric outcomes at month 6 were evaluated and compared between the two treatment groups.
In total, 209 eyes were enrolled; 145 eyes of 77 infants and 64 eyes of 33 infants and were in transscleral and transpupillary groups, respectively. There was no significant difference in baseline characteristics between the groups. There was no significant difference in retreatment rates (1.6% vs. 3.4%; P = 0.669) and progression to stage 4 (1.6% vs. 2.8%; P = 0.999) between the transpupillary and transscleral groups, respectively. At month 6, the mean spherical equivalent was 0.31 ± 3.57 and 0.44 ± 2.85 diopters, and the axial length was 18.28 ± 6.22 and 18.36 ± 6.87 mm in the transpupillary and transscleral groups, respectively, without a significant difference between groups. There was no significant difference in the rate of myopia (43.8% vs. 33.8%; P = 0.169) and high myopia (4.7% vs. 4.8%; P = 0.965) in transpupillary and transscleral groups at month 6.
The transpupillary and transscleral laser photocoagulation routes are both effective in the treatment of zone II type 1 ROP and show no significant differences in anatomical or refractive outcomes in relation to the route chosen.
比较经巩膜二极管与经瞳孔激光光凝治疗 2 区 1 型早产儿视网膜病变（ROP）的解剖学和屈光结果。
在这项前瞻性对照干预性病例系列研究中，根据外科医生的专业领域，将 2 区 1 型 ROP 患儿分为经瞳孔或经巩膜激光治疗。评估并比较两组患儿在第 6 个月时的退行率、再治疗需求以及结构和生物测量结果。
共纳入 209 只眼；77 例婴儿的 145 只眼和 33 例婴儿的 64 只眼分别纳入经巩膜和经瞳孔组。两组患儿的基线特征无显著差异。两组再治疗率（1.6% vs. 3.4%；P = 0.669）和进展至 4 期（1.6% vs. 2.8%；P = 0.999）无显著差异。第 6 个月时，经瞳孔组的平均等效球镜为 0.31 ± 3.57 屈光度，经巩膜组为 0.44 ± 2.85 屈光度；经瞳孔组的眼轴长度为 18.28 ± 6.22mm，经巩膜组为 18.36 ± 6.87mm，两组间无显著差异。第 6 个月时，经瞳孔组和经巩膜组的近视发生率（43.8% vs. 33.8%；P = 0.169）和高度近视发生率（4.7% vs. 4.8%；P = 0.965）无显著差异。
经瞳孔和经巩膜激光光凝途径在治疗 2 区 1 型 ROP 方面均有效，选择的途径不同，在解剖学或屈光结果方面无显著差异。
