Guarner J, Brynes R K, Chan W C, Birdsong G, Hertzler G
Arch Pathol Lab Med. 1987 Mar;111(3):254-6.
We report two cases of primary cardiac lymphoma that developed in patients suffering from the acquired immunodeficiency syndrome. Both cases of lymphoma were histologically aggressive as generally observed in patients with the acquired immunodeficiency syndrome. The lymphoma cells in the center of a tumor nodule obtained from one patient were monoclonal B-cells, whereas those at the periphery showed a polyclonal pattern of staining. It is postulated that this represents a monoclonal lymphoma evolving from a polyclonal B-cell lymphoproliferation analogous to those reported in some cases of lymphoma in immunosuppressed patients infected with Epstein-Barr virus. The lymphoma cells in the other case failed to stain for cytoplasmic immunoglobulins. The possible underlying basis for the increase in incidence of lymphoma in immunodeficiency and the reasons for prevalence of extranodal sites are discussed.
我们报告了两例发生在获得性免疫缺陷综合征患者中的原发性心脏淋巴瘤病例。这两例淋巴瘤在组织学上均具有侵袭性，这在获得性免疫缺陷综合征患者中较为常见。从一名患者获取的肿瘤结节中心的淋巴瘤细胞为单克隆B细胞，而外周的细胞则呈现多克隆染色模式。据推测，这代表了一种从多克隆B细胞淋巴增殖演变而来的单克隆淋巴瘤，类似于在一些感染爱泼斯坦-巴尔病毒的免疫抑制患者的淋巴瘤病例中所报道的情况。另一例中的淋巴瘤细胞未能检测到细胞质免疫球蛋白。文中讨论了免疫缺陷状态下淋巴瘤发病率增加的可能潜在原因以及结外部位高发的原因。
