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生长激素分泌细胞中的肌醇（3,4）二磷酸和肌醇（1,3）二磷酸——肌醇（1,3,4）三磷酸复杂分解的证据

Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells--evidence for complex breakdown of inositol(1,3,4)trisphosphate.

作者信息

Irvine R F, Letcher A J, Lander D J, Heslop J P, Berridge M J

出版信息

Biochem Biophys Res Commun. 1987 Feb 27;143(1):353-9. doi: 10.1016/0006-291x(87)90672-3.

DOI:10.1016/0006-291x(87)90672-3
PMID:3493775
Abstract

Analysis of inositol bisphosphates in GH4 cells labelled with [3H]myo-inositol shows that these cells contain three detectable inositol bisphosphates: inositol(1,4)bisphosphate, and two novel inositol bisphosphates. These latter inositol bisphosphates were degraded by periodate oxidation, borohydride reduction and alkaline phosphatase dephosphorylation; each yielded single non-cyclic alditols, ribitol and threitol, indicating that they must be respectively inositol(1,3)bisphosphate and inositol(3,4) bisphosphate. These two inositol bisphosphates are putative breakdown products of inositol(1,3,4)trisphosphate, and their occurrence suggests a complex route of hydrolysis of inositol(1,3,4)trisphosphate in intact cells.

摘要

用[3H]肌醇标记的GH4细胞中肌醇二磷酸的分析表明，这些细胞含有三种可检测到的肌醇二磷酸：肌醇(1,4)二磷酸和两种新型肌醇二磷酸。后两种肌醇二磷酸可通过高碘酸盐氧化、硼氢化物还原和碱性磷酸酶去磷酸化降解；每种都产生单一的非环状糖醇，核糖醇和苏糖醇，这表明它们必定分别是肌醇(1,3)二磷酸和肌醇(3,4)二磷酸。这两种肌醇二磷酸被认为是肌醇(1,3,4)三磷酸的分解产物，它们的存在表明完整细胞中肌醇(1,3,4)三磷酸的水解途径很复杂。

相似文献

1
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引用本文的文献

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2
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3
Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells.
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Biochem J. 1988 Mar 1;250(2):493-500. doi: 10.1042/bj2500493.
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