Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, China.
The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Angew Chem Int Ed Engl. 2022 Feb 1;61(6):e202115098. doi: 10.1002/anie.202115098. Epub 2021 Dec 23.
Introduction of the trifluoromethyl group (CF ) into organic molecules in an enantioselective manner has attracted significant attention, but still remains a challenging problem. We herein report a catalytic asymmetric trifluoromethylation of cyclic ketones via a Sc /chiral bisoxazoline-catalyzed homologation reaction by employing 2,2,2-trifluorodiazoethane (CF CHN ) as the CF source. This desymmetrization process is highly efficient and generates two chiral centers with excellent diastereoselectivity and enantioselectivity, affording chiral α-trifluoromethyl cyclic ketones in a straightforward manner.
手性双噁唑啉催化的 Sc 催化的环酮同系化反应，通过使用 2,2,2-三氟乙二氮烷（CF CHN ）作为 CF 源，实现了对环状酮的对映选择性三氟甲基化反应。该去对称化过程具有很高的效率，并且以优异的非对映选择性和对映选择性生成两个手性中心，以直接的方式得到手性α-三氟甲基环状酮。
