Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, China.
Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei, China.
Eur J Nucl Med Mol Imaging. 2022 Jul;49(8):2544-2559. doi: 10.1007/s00259-022-05782-0. Epub 2022 Apr 8.
Aptamers are short oligonucleotides that bind to specific target molecules. They have been extensively explored in biomedical applications, including biosensing, medical imaging, and disease treatment. Their adjustable affinity for specific biomarkers stimulates more translational efforts, such as nuclear imaging of tumors in preclinical and clinical settings. In this review, we present recent advances of aptamer-based nuclear imaging and compare aptamer tracers with other biogenic probes in forms of peptides, nanobodies, monoclonal antibodies, and antibody fragments. Fundamental properties of aptamer-based radiotracers are highlighted and potential directions to improve aptamer's imaging performance are discussed. Despite many translational obstacles to overcome, we envision aptamers to be a versatile tool for cancer nuclear imaging in the near future.
适配体是与特定靶分子结合的短寡核苷酸。它们在生物医学应用中得到了广泛的探索，包括生物传感、医学成像和疾病治疗。它们对特定生物标志物的可调亲和力激发了更多的转化努力，例如临床前和临床环境中肿瘤的核成像。在这篇综述中，我们介绍了基于适配体的核成像的最新进展，并将适配体示踪剂与其他生物探针（如肽、纳米抗体、单克隆抗体和抗体片段）进行了比较。强调了基于适配体的放射性示踪剂的基本特性，并讨论了提高适配体成像性能的潜在方向。尽管还有许多需要克服的转化障碍，但我们设想适配体在不久的将来将成为癌症核成像的一种多功能工具。
