Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Institut Universitaire de France, 1 rue Descartes, 75231, Paris, France.
Chemistry. 2018 Jul 20;24(41):10339-10343. doi: 10.1002/chem.201802685. Epub 2018 Jun 25.
An efficient catalytic enantioselective access to chiral functionalized trifluoromethyl cyclopropanes from two classes of diazo compounds and α-trifluoromethyl styrenes using Rh ((S)-BTPCP) as a catalyst is described. This method provides an efficient and practical strategy for the synthesis of highly functionalized CF -cyclopropanes with excellent diastereoselectivities (up to 20:1) and enantioselectivities (up to 99 % ee). The depicted methodology represents, to date, the most efficient catalytic enantioselective method to access highly decorated chiral CF -cyclopropanes. Extension to chiral monohalomethyl cyclopropanes in high ee is also reported.
一种高效的催化对映选择性方法，使用 Rh((S)-BTPCP) 作为催化剂，从两类重氮化合物和α-三氟甲基苯乙烯中获得手性官能化的三氟甲基环丙烷。该方法为合成具有高对映选择性（高达 20:1）和高对映选择性（高达 99%ee）的高度官能化 CF-环丙烷提供了一种有效且实用的策略。所描述的方法代表了迄今为止获得高度装饰的手性 CF-环丙烷的最有效的催化对映选择性方法。还报道了高对映选择性的手性单卤代甲基环丙烷的扩展。
