Henry C A, Ungchusri T, Charbeneau T D, Winford T E
J Periodontol. 1987 Mar;58(3):177-86. doi: 10.1902/jop.1987.58.3.177.
This study assessed the phagocytosis of polymorphonuclear neutrophils and the opsonic capacity of serum in experimental human gingivitis. Relationships were sought among these two measurements, clinical indices of gingivitis and complement-related opsonins. Measurements of chemiluminescence provided an index of phagocytosis and of opsonic capacity. Test group Plaque Index scores were higher than the control group on Days 7, 14, and 21, while the Gingival Index of the test group was elevated only on Day 21. Phagocytosis of test subjects' PMNs and opsonic capacity of their sera were no different from that of the controls'. Levels of C3 in both nonactivated and activated sera of the test group were significantly lower than that of the control group only on Day 14. In the test group, differences of per cent C3 conversion occurred between Days 14 and 21, and Plaque Index scores were inversely correlated with the order of per cent C3 data on these same days. Our results also indicate that complement contributes significantly to the serum opsonic capacity. The levels of developing plaque and subsequent gingival inflammation are apparently related to the degree of complement activation.
本研究评估了实验性人类牙龈炎中多形核中性粒细胞的吞噬作用以及血清的调理能力。探寻了这两项测量指标、牙龈炎临床指标与补体相关调理素之间的关系。化学发光测量提供了吞噬作用和调理能力的指标。试验组在第7天、14天和21天的菌斑指数得分高于对照组，而试验组的牙龈指数仅在第21天升高。试验对象的多形核中性粒细胞吞噬作用及其血清调理能力与对照组无异。试验组未激活血清和激活血清中的C3水平仅在第14天显著低于对照组。在试验组中，第14天和21天之间C3转化率存在差异，且菌斑指数得分与这些相同日期的C3数据百分比顺序呈负相关。我们的结果还表明补体对血清调理能力有显著贡献。菌斑形成和随后的牙龈炎症程度显然与补体激活程度有关。
