他莫昔芬对体外商陆丝裂原刺激的免疫球蛋白分泌的影响。
Effect of tamoxifen on pokeweed mitogen stimulated immunoglobulin secretion in vitro.
作者信息
Baral E, Blomgren H, Wasserman J, Rotstein S, von Stedingk L V
出版信息
J Clin Lab Immunol. 1986 Nov;21(3):137-9.
PMID:3494130
Abstract
The influence of Tamoxifen on pokeweed mitogen induced immunoglobulin (Ig) secretion of human blood lymphocytes was tested in vitro. It was observed that pretreatment of T cell enriched preparations with "therapeutic" concentrations of Tamoxifen augmented their capacity to promote IgG but not IgM secretion of untreated autologous B-lymphocytes. Cultures containing Tamoxifen pretreated B cell enriched preparations and untreated T cells exhibited reduced secretion of both IgG and IgM.
摘要
在体外试验了他莫昔芬对美洲商陆有丝分裂原诱导的人血淋巴细胞免疫球蛋白（Ig）分泌的影响。观察到，用“治疗”浓度的他莫昔芬对富含T细胞的制剂进行预处理，可增强其促进未处理的自体B淋巴细胞分泌IgG而非IgM的能力。含有经他莫昔芬预处理的富含B细胞的制剂和未处理的T细胞的培养物中，IgG和IgM的分泌均减少。
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