Stanner Heather, Zelig Rena, Rigassio Radler Diane
Department of Clinical and Preventive Nutrition Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
Coram CVS/Specialty Infusion Services, Austin, TX, USA.
JPEN J Parenter Enteral Nutr. 2022 May;46(4):757-770. doi: 10.1002/jpen.2317. Epub 2022 Feb 16.
Home parenteral nutrition (HPN) may be needed as a long-term therapy for patients with chronic intestinal failure whose clinical condition does not allow complete weaning of the parenteral nutrition (PN) solution. HPN is a time-consuming and clinically complex therapy and can negatively affect quality of life (QOL). The level of dependency on HPN, specifically, infusion frequency, has been proposed as a factor that may have an effect on QOL in patients receiving HPN. The primary aim of this qualitative review is to identify the impact of HPN frequency (days per week of HPN infusion) on QOL measurements in adult patients receiving HPN. A comprehensive literature search was completed in PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. Primary clinical research studies were included if they were conducted in adult patients receiving HPN and included the assessment of the associations between the frequency of HPN infusion and QOL measurements. Six articles ultimately met the criteria for this review. There was variability among the studies, including use of different tools to measure QOL. However, all six studies suggest that a reduction in HPN frequency may be associated with an improvement in QOL. Whenever patients' clinical situation allows, a reduction in HPN frequency should be considered to improve QOL in patients receiving HPN.
对于临床状况不允许完全停用肠外营养（PN）溶液的慢性肠衰竭患者，可能需要长期进行家庭肠外营养（HPN）治疗。HPN是一种耗时且临床操作复杂的治疗方法，会对生活质量（QOL）产生负面影响。HPN的依赖程度，特别是输注频率，被认为是可能影响接受HPN治疗患者生活质量的一个因素。本定性综述的主要目的是确定HPN频率（每周HPN输注天数）对接受HPN治疗的成年患者生活质量测量结果的影响。我们在PubMed和护理及相关健康文献累积索引（CINAHL）数据库中完成了全面的文献检索。如果主要临床研究是在接受HPN治疗的成年患者中进行的，并且包括对HPN输注频率与生活质量测量之间关联的评估，则纳入这些研究。最终有六篇文章符合本综述的标准。这些研究之间存在差异，包括使用不同的工具来测量生活质量。然而，所有六项研究均表明，降低HPN频率可能与生活质量的改善相关。只要患者的临床情况允许，就应考虑降低HPN频率，以改善接受HPN治疗患者的生活质量。
