Alonso M A, Weissman S M
Proc Natl Acad Sci U S A. 1987 Apr;84(7):1997-2001. doi: 10.1073/pnas.84.7.1997.
We have isolated a human cDNA that is expressed in the intermediate and late stages of T-cell differentiation. The cDNA encodes a highly hydrophobic protein, termed MAL, that lacks a hydrophobic leader peptide sequence and contains four potential transmembrane domains separated by short hydrophilic segments. The predicted configuration of the MAL protein resembles the structure of integral proteins that form pores or channels in the plasma membrane and that are believed to act as transporters of water-soluble molecules and ions across the lipid bilayer. The presence of MAL mRNA in a panel of T-cell lines that express both the T-cell receptor and the T11 antigen suggests that MAL may be involved in membrane signaling in T cells activated via either T11 or T-cell receptor pathways.
我们分离出了一种在T细胞分化的中期和后期表达的人类cDNA。该cDNA编码一种高度疏水的蛋白质，称为MAL，它缺乏疏水前导肽序列，包含四个由短亲水片段分隔的潜在跨膜结构域。MAL蛋白的预测结构类似于在质膜中形成孔或通道的整合蛋白的结构，据信这些整合蛋白可作为水溶性分子和离子跨脂质双层的转运体。在一组同时表达T细胞受体和T11抗原的T细胞系中存在MAL mRNA，这表明MAL可能参与通过T11或T细胞受体途径激活的T细胞中的膜信号传导。
