Lin Yan, Wang Xiangtian, Lenz Luciane, Ndiaye Ousmane, Qin Jian, Wang Xiaoli, Huang Hui, Jeuland Marc A, Zhang Junfeng
Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC 27705, USA.
RWI Leibniz Institute for Economic Research, 10115 Berlin, Germany.
Antioxidants (Basel). 2021 Dec 20;10(12):2026. doi: 10.3390/antiox10122026.
Blood biomarkers of oxidative stress and inflammation have been associated with increased risk of hypertension development; yet their application in sub-Saharan Africa has been limited due to the lack of blood collection facilities. In this study, we evaluated the usefulness of dried blood spots (DBS), a more feasible alternative to venous blood, in rural sub-Saharan residents. We recruited 342 women with incident hypertension from rural Senegal, and measured C-reactive protein (CRP) and malondialdehyde (MDA) in DBS and concurrent blood pressure (BP) at baseline and 1-year follow-up. Associations of DBS biomarkers with current levels of and 1-year changes in BP were examined after adjusting for demographic, medical, and socioeconomic covariates. DBS concentrations of MDA were significantly associated with concurrent systolic BP (SBP) ( < 0.05), while DBS baseline concentrations of CRP were associated with longitudinal changes in SBP between baseline and follow-up. Compared to participants with baseline CRP < 1 mg/L, those with CRP of 1-3 mg/L and 3-10 mg/L had 2.11 mmHg (95%CI: -2.79 to 7.02 mmHg) and 4.68 mmHg (95%CI: 0.01 to 9.36 mmHg) increases in SBP at follow-up, respectively. The results support the use of DBS biomarkers for hypertension prevention and control, especially in settings with limited clinical resources.
氧化应激和炎症的血液生物标志物与高血压发病风险增加有关；然而，由于缺乏采血设施，它们在撒哈拉以南非洲地区的应用受到限制。在本研究中，我们评估了干血斑（DBS）这种比静脉血更可行的替代方法在撒哈拉以南农村居民中的实用性。我们从塞内加尔农村招募了342名新发高血压女性，在基线和1年随访时测量了DBS中的C反应蛋白（CRP）和丙二醛（MDA）以及同时测量的血压（BP）。在调整了人口统计学、医学和社会经济协变量后，研究了DBS生物标志物与当前血压水平及1年血压变化的关联。DBS中MDA的浓度与同时期收缩压（SBP）显著相关（<0.05），而DBS中CRP的基线浓度与基线至随访期间SBP的纵向变化相关。与基线CRP<1mg/L的参与者相比，CRP为1 - 3mg/L和3 - 10mg/L的参与者在随访时SBP分别升高了2.11mmHg（95%CI：-2.79至7.02mmHg）和4.68mmHg（95%CI：0.01至9.36mmHg）。结果支持使用DBS生物标志物进行高血压的预防和控制，尤其是在临床资源有限的环境中。
