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成骨不全症患者股骨骨折的数值分析

Bone Fractures Numerical Analysis in a Femur Affected by Osteogenesis Imperfecta.

作者信息

Ramírez-Vela Viridiana, Aguilar-Pérez Luis Antonio, Paredes-Rojas Juan Carlos, Flores-Campos Juan Alejandro, Ortiz-Hernández Fernando ELi, Torres-SanMiguel Christopher René

机构信息

Instituto Politécnico Nacional, Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Zacatenco, Sección de Estudios de Posgrado e Investigación, Ciudad de Mexico 07738, Mexico.

Instituto Politécnico Nacional, Centro Mexicano para la Producción más Limpia, Ciudad de Mexico 07340, Mexico.

出版信息

Children (Basel). 2021 Dec 14;8(12):1177. doi: 10.3390/children8121177.

DOI:10.3390/children8121177
PMID:34943373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8700594/
Abstract

This work presents a non-invasive methodology to obtain a three-dimensional femur model of three-year-old infants affected with Osteogenesis Imperfecta (OI) type III. DICOM Files of a femur were processed to obtain a finite element model to assess the transverse, the oblique, and the comminuted fractures. The model is evaluated under a normal walking cycle. The loads applied were considered the most critical force generated on the normal walking cycle, and the analyses considered anisotropic bone conditions. The outcome shows stress concentration areas in the central zone of the diaphysis of the femur, and the highest levels of stress occur in the case of the comminuted fracture, while the transverse fracture presents the lowest values. Thus, the method can be helpful for determining the bone fracture behavior of certain pathologies, such as osteogenesis imperfecta, osteopenia, and osteoporosis.

摘要

这项工作提出了一种非侵入性方法，用于获取患有III型成骨不全症（OI）的三岁婴儿的三维股骨模型。对股骨的DICOM文件进行处理，以获得有限元模型，用于评估横向、斜向和粉碎性骨折。该模型在正常步行周期下进行评估。所施加的载荷被认为是正常步行周期中产生的最关键力，并且分析考虑了各向异性骨条件。结果显示，在股骨骨干的中央区域存在应力集中区域，在粉碎性骨折情况下应力水平最高，而横向骨折的应力值最低。因此，该方法有助于确定某些病症（如成骨不全症、骨质减少和骨质疏松症）的骨折行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30c7/8700594/f77f95517ee0/children-08-01177-g020.jpg
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本文引用的文献

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Investigating the mechanical response of paediatric bone under bending and torsion using finite element analysis.运用有限元分析研究小儿骨骼在弯曲和扭转下的力学响应。
Biomech Model Mechanobiol. 2018 Aug;17(4):1001-1009. doi: 10.1007/s10237-018-1008-9. Epub 2018 Mar 10.
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[Epidemiology of Imperfect Osteogenesis: a Rare Disease in the Valencia Region.].
[成骨不全的流行病学：巴伦西亚地区的一种罕见疾病。]
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The History of Biomechanics in Total Hip Arthroplasty.全髋关节置换术中生物力学的历史
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Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments.使用从双能X线吸收法（DXA）图像重建的三维有限元模型预测股骨强度：与实验结果的验证
Biomech Model Mechanobiol. 2017 Jun;16(3):989-1000. doi: 10.1007/s10237-016-0866-2. Epub 2016 Dec 21.
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Atypical Femur Fractures in Patients Treated with Bisphosphonates: Identification, Management, and Prevention.接受双膦酸盐治疗患者的非典型股骨骨折：识别、处理与预防
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Advances in imaging approaches to fracture risk evaluation.骨折风险评估成像方法的进展。
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The clinical features of osteogenesis imperfecta in Vietnam.越南成骨不全症的临床特征。
Int Orthop. 2017 Jan;41(1):21-29. doi: 10.1007/s00264-016-3315-z. Epub 2016 Nov 2.
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