Lundblad L, Lundberg J M, Anggård A, Zetterström O
Allergy. 1987 Jan;42(1):20-5. doi: 10.1111/j.1398-9995.1987.tb02182.x.
The effects of local capsaicin pretreatment on the cutaneous triple response reaction induced by allergen exposure or anti-IgE were studied in man. Acute exposure of the human skin to capsaicin caused a burning sensation and a clearcut flare reaction but no wheal response. Upon repeated administration these local reactions to capsaicin disappeared. The flare component and the subjective itching sensation of the cutaneous allergy reaction to rat antigen in sensitized persons or anti-IgE in non-allergic persons were then markedly reduced. Two weeks after capsaicin pretreatment the flare response to allergen was not significantly changed compared to the control reaction, suggesting a reversible effect of capsaicin treatment. The wheal component of the allergy or anti-IgE reaction was, however, not influenced by capsaicin pretreatment, indicating that the wheal and flare components are caused by different mechanisms. It is concluded that capsaicin sensitive sensory nerves are of importance for the human cutaneous triple response reaction induced by allergen exposure. Thus, secondary release of mediators, such as CGRP or tachykinins from sensory nerve branches, may contribute to the flare component of this reaction. Furthermore the itching sensation seems to be dependent to a large extent on capsaicin-sensitive nerves. However, sensory nerves seem to have less importance for the wheal reaction, i.e. the protein extravasation response.
在人体中研究了局部辣椒素预处理对变应原暴露或抗IgE诱导的皮肤三联反应的影响。人体皮肤急性接触辣椒素会引起烧灼感和明显的红斑反应，但无风团反应。反复给药后，对辣椒素的这些局部反应消失。然后，致敏者对大鼠抗原或非过敏者对抗IgE的皮肤过敏反应的红斑成分和主观瘙痒感明显减轻。辣椒素预处理两周后，与对照反应相比，对变应原的红斑反应无明显变化，提示辣椒素治疗具有可逆性作用。然而，过敏或抗IgE反应的风团成分不受辣椒素预处理的影响，表明风团和红斑成分由不同机制引起。结论是，辣椒素敏感的感觉神经对变应原暴露诱导的人体皮肤三联反应很重要。因此，感觉神经分支中降钙素基因相关肽或速激肽等介质的二次释放可能有助于该反应的红斑成分。此外，瘙痒感似乎在很大程度上依赖于辣椒素敏感神经。然而，感觉神经对风团反应（即蛋白质外渗反应）的重要性似乎较小。
