Dobenecker Britta, Kienzle Ellen, Siedler Stephanie
Chair of Animal Nutrition and Dietetics, Department of Veterinary Science, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Schönleutnerstrasse 8, D-85764 Oberschleissheim, Germany.
Animals (Basel). 2021 Dec 4;11(12):3456. doi: 10.3390/ani11123456.
Elevated serum phosphate concentrations are an established risk factor for cardiovascular disease and mortality in chronic kidney disease in various species. Independent associations of other parameters of phosphorus metabolism, such as phosphorus intake from different sources and serum concentrations of phosphorus, as well as parameters involved in the regulation, such as parathyroid hormone (PTH) or markers of bone turnover, have been studied in less detail. Therefore, the serum kinetics of phosphate, PTH, and the bone resorption marker bone-specific alkaline phosphatase (BAP) were investigated after 18 days of feeding a control diet and diets supplemented with eight different organic and inorganic phosphate sources aiming at 1.8% phosphorus per dry matter and calcium to phosphorus ratio between 1.3 and 1.7 to 1. Eight healthy beagle dogs (f/m, 2-4 years, 12.9 ± 1.4 kg body weight) were available for the trial. Highly significant differences in the serum kinetics of phosphorus, PTH, and BAP with the highest postprandial levels after feeding highly water-soluble sodium and potassium phosphates were found. We conclude that the use of certain inorganic phosphates in pet food is potentially harmful and should be restricted.
血清磷酸盐浓度升高是各种物种慢性肾脏病中心血管疾病和死亡的既定危险因素。磷代谢的其他参数，如不同来源的磷摄入量和血清磷浓度，以及参与调节的参数，如甲状旁腺激素（PTH）或骨转换标志物，其独立关联的研究较少。因此，在喂食对照饮食和添加了八种不同有机和无机磷源的饮食18天后，研究了磷酸盐、PTH和骨吸收标志物骨特异性碱性磷酸酶（BAP）的血清动力学，目标是每干物质含磷1.8%，钙磷比在1.3至1.7比1之间。八只健康的比格犬（雌雄不限，2 - 4岁，体重12.9±1.4千克）可用于该试验。研究发现，喂食高度水溶性的钠和钾磷酸盐后，磷、PTH和BAP的血清动力学存在高度显著差异，餐后水平最高。我们得出结论，宠物食品中使用某些无机磷酸盐可能有害，应加以限制。
