用于胃肠道给药的机器人胶囊概述。
An Overview of Robotic Capsules for Drug Delivery to the Gastrointestinal Tract.
作者信息
Cortegoso Valdivia Pablo, Robertson Alexander R, De Boer Nanne K H, Marlicz Wojciech, Koulaouzidis Anastasios
机构信息
Gastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, 43121 Parma, Italy.
Department of Gastroenterology, Western General Hospital, Edinburgh EH4 2XU, UK.
出版信息
J Clin Med. 2021 Dec 10;10(24):5791. doi: 10.3390/jcm10245791.
The introduction of capsule endoscopy two decades ago marked the beginning of the "small bowel revolution". Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of the gastrointestinal (GI) tract, several DDS have been developed, including many prototypes being designed, built and eventually produced with ingenious drug-release mechanisms and anchoring systems allowing targeted therapy. This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.
二十年前胶囊内镜的引入标志着“小肠革命”的开端。从那时起，微技术的迅速发展使得药物递送系统（DDS）得以开发，旨在满足一些标准药物递送无法满足的需求。为了克服胃肠道复杂的解剖结构和生理特性，人们开发了多种DDS，包括许多正在设计、制造并最终生产出来的原型，这些原型具有巧妙的药物释放机制和锚定系统，能够实现靶向治疗。本文综述重点介绍了目前可用的胃肠道药物递送系统，并讨论了这些技术的需求、局限性及未来考量。
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