Fihman Vincent, Faury Hélène, Moussafeur Amina, Huguet Raphaelle, Galy Adrien, Gallien Sébastien, Lim Pascal, Lepeule Raphaël, Woerther Paul-Louis
Bacteriology and Infection Control Unit, Department of Prevention, Diagnosis, and Treatment of Infections, Henri-Mondor University Hospital, AP-HP, 94000 Creteil, France.
EA 7380 Dynamyc, EnvA, UPEC, Paris-Est University, 94000 Creteil, France.
J Clin Med. 2021 Dec 13;10(24):5824. doi: 10.3390/jcm10245824.
To assess the need for prolonged incubation of blood culture bottles beyond five days for the diagnosis of infectious endocarditis (IE), we conducted a retrospective cohort study of 6109 sets of two blood culture bottles involving 1211 patients admitted to the Henri Mondor University Hospital for suspicion of IE between 1 January 2016 and 31 December 2019. Among the 322 patients with IE, 194 had positive blood cultures in our centre. Only one patient with a time-to-positivity blood culture of more than 120 h (5 days) was found. The main cause for the 22 patients with positive blood cultures after five days was contamination with . Our results do not support extending the duration of incubation of blood culture bottles beyond five days for the diagnosis of infectious endocarditis, with the exception of patients with risk factors for infection.
为评估血培养瓶延长培养5天以上对感染性心内膜炎（IE）诊断的必要性，我们进行了一项回顾性队列研究，纳入了2016年1月1日至2019年12月31日期间因疑似IE入住亨利·蒙多大学医院的1211例患者的6109套两瓶血培养标本。在322例IE患者中，194例在我们中心血培养呈阳性。仅发现1例血培养阳性时间超过120小时（5天）的患者。5天后血培养阳性的22例患者的主要原因是污染。我们的结果不支持将血培养瓶的培养时间延长至5天以上用于感染性心内膜炎的诊断，但有感染危险因素的患者除外。
