Muzahim Yasameen E, Parish David C, Goyal Hemant
Department of Internal Medicine, Atrium Health-Navicent, Macon, GA 31201, USA.
Department of Internal Medicine, Mercer University School of Medicine, Macon, GA 31207, USA.
J Clin Med. 2021 Dec 16;10(24):5902. doi: 10.3390/jcm10245902.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily affects the lungs, causing respiratory symptoms. However, the infection clearly affects all organ systems including the gastrointestinal system. Acute pancreatitis associated with coronavirus disease 2019 (COVID-19) has been widely reported Recent studies have discussed pancreatic compromise incidentally in asymptomatic patients, or in a form of clinical symptoms such as abdominal pain, nausea, or vomiting, which is further reflected in some cases with abnormal serum lipase and amylase levels It was suggested that upregulation of angiotensin-converting enzyme II cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 positive patients To date, there is insufficient data to establish the causality of acute pancreatitis in SARS-CoV-2 infected cases. In this paper, we organize recent studies conducted to observe the frequency of acute pancreatitis associated with COVID-19 cases while highlighting present hypotheses, predisposing factors, and their effect on the outcome, and point to gaps in our knowledge.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要影响肺部，引发呼吸道症状。然而，该感染显然会影响包括胃肠系统在内的所有器官系统。与2019冠状病毒病（COVID-19）相关的急性胰腺炎已被广泛报道。最近的研究讨论了无症状患者偶然出现的胰腺损害，或以腹痛、恶心或呕吐等临床症状的形式出现，这在一些血清脂肪酶和淀粉酶水平异常的病例中进一步得到体现。有人提出，血管紧张素转换酶II细胞受体或炎性细胞因子的上调在SARS-CoV-2阳性患者胰腺损伤的易感性中起主要作用。迄今为止，尚无足够数据确定SARS-CoV-2感染病例中急性胰腺炎的因果关系。在本文中，我们整理了最近进行的研究，以观察与COVID-19病例相关的急性胰腺炎的发生率，同时突出当前的假说、易感因素及其对预后的影响，并指出我们知识上的空白。
