Institute for Translational Medicine, University of Pécs, Medical School, Pécs 7624, Hungary.
Doctoral School of Clinical Medicine, University of Szeged, Szeged 6720, Hungary.
World J Gastroenterol. 2020 Oct 28;26(40):6270-6278. doi: 10.3748/wjg.v26.i40.6270.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 could be an etiological factor in acute pancreatitis (AP).
To assess all the available evidence in the literature relating to coronavirus disease 2019 (COVID-19) and AP.
We performed a systematic review of the available literature on the topic. The systematic search was conducted on 15 May 2020 on MEDLINE, EMBASE, CENTRAL, Web of Science and Scopus with a search key using the terms "amylase," "lipase," "pancr*," "COVID-19" and synonyms. Due to the low quality and poor comparability of the studies, a meta-analysis was not performed.
Six case reports and two retrospective cohorts were included, containing data on eleven COVID-19 patients with AP. Five patients had AP according to the Atlanta classification. Other publications did not provide sufficient information on the diagnostic criteria. Most cases were considered SARS-CoV-2-induced, while several established etiological factors were not investigated. We were able to identify other possible causes in most of them.
We strongly highlight the need for adherence to the guidelines during a diagnostic and etiological workup, which could alter therapy.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染，主要引起呼吸道症状，也已知会影响胃肠道。有几项病例报告假设 SARS-CoV-2 可能是急性胰腺炎（AP）的病因。
评估与 2019 年冠状病毒病（COVID-19）和 AP 相关的所有现有文献证据。
我们对该主题的现有文献进行了系统评价。系统检索于 2020 年 5 月 15 日在 MEDLINE、EMBASE、CENTRAL、Web of Science 和 Scopus 上进行，使用“淀粉酶”、“脂肪酶”、“胰*”、“COVID-19”和同义词作为检索词。由于研究的质量低且可比性差，因此未进行荟萃分析。
纳入了 6 例病例报告和 2 项回顾性队列研究，共包含 11 例 COVID-19 合并 AP 患者的数据。5 例患者根据亚特兰大分类标准患有 AP。其他出版物没有提供有关诊断标准的足够信息。大多数病例被认为是由 SARS-CoV-2 引起的，而几个已确立的病因未被调查。在大多数病例中，我们能够确定其他可能的病因。
我们强烈强调在诊断和病因学检查期间需要遵守指南，这可能会改变治疗方法。
