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通过暴露边际法测定薯片和其他零食中的丙烯酰胺含量及暴露风险评估。

Determination of acrylamide levels in potato crisps and other snacks and exposure risk assessment through a Margin of Exposure approach.

作者信息

Esposito Francesco, Nardone Antonio, Fasano Evelina, Triassi Maria, Cirillo Teresa

机构信息

Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100 - 80055 Portici, Naples, Italy.

Department of Public Health, University of Naples Federico II, Via Sergio Pansini, 5 - 80131 Naples, Italy.

出版信息

Food Chem Toxicol. 2017 Oct;108(Pt A):249-256. doi: 10.1016/j.fct.2017.08.006. Epub 2017 Aug 12.

Abstract

Potato crisps, corn-based extruded snacks and other savoury snacks are very popular products especially among younger generations. These products could be a potential source of acrylamide (AA), a toxic compound which could develop during frying and baking processes. The purpose of this study was the assessment of the dietary intake to AA across six groups of consumers divided according to age through the consumption of potato crisps and other snacks, in order to eventually evaluate the margin of exposure (MOE) related to neurotoxic and carcinogenic critical endpoints. Different brands of potato crisps and other popular snacks were analyzed through a matrix solid-phase dispersion method followed by a bromination step and GC-MS quantification. The concentration of detected AA ranged from 21 to 3444 ng g and the highest level occurred in potato crisps samples which showed a median value of 968 ng g. The risk characterization through MOE assessment revealed that five out of six consumers groups showed higher exposure values associated with an augmented carcinogenic risk.

摘要

薯片、玉米挤压零食和其他咸味零食是非常受欢迎的产品,尤其在年轻一代中。这些产品可能是丙烯酰胺(AA)的潜在来源,丙烯酰胺是一种在油炸和烘焙过程中可能产生的有毒化合物。本研究的目的是通过食用薯片和其他零食,评估六组按年龄划分的消费者对丙烯酰胺的膳食摄入量,以便最终评估与神经毒性和致癌关键终点相关的暴露边际(MOE)。通过基质固相分散法,随后进行溴化步骤和气相色谱 - 质谱定量分析,对不同品牌的薯片和其他流行零食进行了分析。检测到的丙烯酰胺浓度范围为21至3444纳克/克,最高水平出现在薯片样品中,其中位数为968纳克/克。通过MOE评估进行的风险特征分析表明,六组消费者中有五组显示出较高的暴露值,与致癌风险增加相关。

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