Department of Anatomy and Radiology, Health Sciences Faculty, GIR of Physical Exercise and Aging, Campus Universitario "Los Pajaritos", 42004 Soria, Spain.
Spine Department, Valladolid University Hospital, University of Valladolid, 47005 Valladolid, Spain.
Medicina (Kaunas). 2021 Dec 2;57(12):1321. doi: 10.3390/medicina57121321.
Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection.
疫苗是降低 SARS-CoV-2 感染相关发病率的唯一途径。新突变的出现促使我们提高疫苗的有效性，作为一种补充手段。在这种情况下，佐剂策略的使用提高了针对登革热、流感和普通感冒等病毒感染的不同疫苗的有效性。最近关于 COVID-19 感染者的报告显示，循环维生素 D 水平低与严重呼吸功能不全相关。这种微量营养素的免疫调节活性可减弱促炎细胞因子的合成，同时增加抗体产生。因此，本综述提出将维生素 D 用作佐剂微量营养素，以提高针对 SARS-CoV-2 感染的疫苗的功效。
