Laboratorio de Biología Celular y Molecular, Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, Querétaro, Mexico.
Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Av. Sábalo Cerritos S/N, S/C, Mazatlán 82112, Sinaloa, Mexico.
Molecules. 2021 Dec 18;26(24):7670. doi: 10.3390/molecules26247670.
Angiogenesis, the formation of new blood vessels, underlies tissue development and repair. Some medicinal plant-derived compounds can modulate the angiogenic response. , a Mexican medicinal plant, is widely used because of its effects on pain and inflammation. The main bioactive phytochemicals from roots are alkamides, where affinin is the most abundant. Scientific studies show various medical effects of organic extracts of roots and affinin that share some molecular pathways with the angiogenesis process, with the vasodilation mechanism of action being the most recent. This study investigates whether pure affinin and the ethanolic extract from roots (HLEE) promote angiogenesis. Using the aortic ring rat assay (ex vivo method) and the direct in vivo angiogenesis assay, where angioreactors were implanted in CD1 female mice, showed that affinin and the HLEE increased vascular growth in a dose-dependent manner in both bioassays. This is the first study showing the proangiogenic effect of . Further studies should focus on the mechanism of action and its possible therapeutic use in diseases characterized by insufficient angiogenesis.
血管生成，即新血管的形成，是组织发育和修复的基础。一些药用植物衍生的化合物可以调节血管生成反应。是一种墨西哥药用植物，由于其对疼痛和炎症的作用而被广泛使用。根中的主要生物活性植物化学物质是酰胺类化合物，其中 affinin 是最丰富的。科学研究表明，根的有机提取物和 affinin 具有多种医学作用，它们与血管生成过程的一些分子途径共享，其中血管扩张作用机制是最近才发现的。本研究旨在探讨纯 affinin 和 根的乙醇提取物（HLEE）是否促进血管生成。使用大鼠主动脉环试验（离体方法）和直接体内血管生成试验（将 Angioreactors 植入 CD1 雌性小鼠），结果表明 affinin 和 HLEE 在两种生物测定中均以剂量依赖性方式促进血管生长。这是首次研究表明 具有促血管生成作用。进一步的研究应集中在其作用机制及其在以血管生成不足为特征的疾病中的潜在治疗用途上。
