Programa Multidisciplinario de Posgrado en Ciencias Ambientales, UASLP San Luis Potosí, México.
Pharm Biol. 2010 Feb;48(2):195-200. doi: 10.3109/13880200903078495.
Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been investigated yet. The objectives of this study were to evaluate the analgesic action of affinin and the H. longipes root ethanol extract, as well as their effects on the NS using an animal model. The ethanol extract was obtained by maceration, and affinin was purified from it through chromatographic techniques. Chemical and thermal analgesia were used to assess their analgesic proprieties. Irwin's test was used to evaluate their stimulating or depressing effects. The ethanol extract and affinin displayed analgesic action similar to ketorolac and stimulating effect comparable to caffeine on the nervous system of adult mice.
长柄山蚂蚱腿子（菊科：向日葵族）（chilcuague）被墨西哥传统医学用于对抗寄生虫和缓解牙痛和肌肉疼痛。其杀菌效果已经过实验证明；然而，其镇痛作用及其对神经系统的作用尚未得到研究。本研究的目的是评估 affinin 和长柄山蚂蚱腿子根乙醇提取物的镇痛作用，以及它们在动物模型中对神经系统的影响。乙醇提取物通过浸提获得，affinin 通过色谱技术从其中纯化得到。化学和热镇痛用于评估它们的镇痛特性。Irwin 试验用于评估它们对成年小鼠神经系统的刺激或抑制作用。乙醇提取物和 affinin 表现出与酮咯酸类似的镇痛作用，对神经系统的刺激作用与咖啡因相当。
