Yang Xianli, Zhao Zhiyong, Wang Jianhua, Yang Junhua, E Hengchao, Chen Bo, He Pengzhen, Tan Yanglan, Zhou Changyan
Laboratory of Quality & Safety Risk Assessment for Agro-Products (Shanghai), Institute for Agro-Food Standards and Testing Technology, Ministry of Agriculture, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
Shanghai Co-Elite Agro-Food Testing Technical Service Co., Ltd., Shanghai 201106, China.
J Fungi (Basel). 2021 Nov 26;7(12):1015. doi: 10.3390/jof7121015.
Deoxynivalenol (DON) is one of the major mycotoxins that contaminate cereals. In this study, we determined the DON level in wheat-based products from Chinese five main production areas collected in Shanghai and calculated the daily intake of DON for inhabitants using the point evaluation and the probabilistic evaluation based on Monte Carlo simulation. The results showed the positive rates of DON in the products were higher than 80.0%, with the concentrations ranging from 41.8 to 1110 µg/kg. The estimated mean daily intakes of DON for 7- to 10-year-old children and adults groups were below 1 µg/kg bw/day, the provisional maximum tolerable daily intake (PMTDI) set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), suggesting no health risks for the consumers. However, the 99th percentiles of dietary DON exposures for children and adults exceeded the PMTDI, indicating adverse health effects might occur if the two groups intake highly contaminated wheat-based products. The potential health risks for the two groups exposed to DON in the wheat-based products from the Middle and Lower Yangtze Valley (MLYV) were higher than those from the other areas in China.
脱氧雪腐镰刀菌烯醇（DON）是污染谷物的主要霉菌毒素之一。在本研究中，我们测定了从上海采集的中国五个主要产区的小麦制品中DON的含量，并基于蒙特卡洛模拟，采用点评估法和概率评估法计算了居民DON的每日摄入量。结果表明，产品中DON的阳性率高于80.0%，浓度范围为41.8至1110 µg/kg。7至10岁儿童组和成人组DON的估计平均每日摄入量低于联合国粮食及农业组织/世界卫生组织食品添加剂联合专家委员会（JECFA）设定的暂定每日最大耐受摄入量（PMTDI）1 µg/kg bw/天，这表明消费者不存在健康风险。然而，儿童和成人膳食中DON暴露量的第99百分位数超过了PMTDI，这表明如果这两组人群摄入高度污染的小麦制品，可能会对健康产生不利影响。长江中下游流域（MLYV）小麦制品中DON暴露的两组人群的潜在健康风险高于中国其他地区。
