Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Int J Mol Sci. 2021 Dec 19;22(24):13615. doi: 10.3390/ijms222413615.
Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed.
对肌肉组织中离子通道的研究主要集中在生理肌肉功能和相关疾病上，但新出现的证据支持离子通道和转运蛋白在发育过程中起着关键作用，例如控制干细胞的成肌细胞分化。在这篇综述中，我们概述了影响骨骼肌成肌细胞分化、多能干细胞向心肌分化以及血管平滑肌细胞分化的离子通道和转运蛋白。我们强调了离子通道突变的模型生物或患者的例子。此外，还讨论了涉及静息膜电位超极化和一系列钙信号的潜在分子机制。
