体外重现人类成肌细胞发生的人多能干细胞。
Recapitulating human myogenesis ex vivo using human pluripotent stem cells.
机构信息
Department of Microbiology, Immunology and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA.
Department of Microbiology, Immunology and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA.
出版信息
Exp Cell Res. 2022 Feb 15;411(2):112990. doi: 10.1016/j.yexcr.2021.112990. Epub 2021 Dec 30.
Human pluripotent stem cells (hPSCs) provide a human model for developmental myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs into muscle stem cells has the potential to provide a cell-based therapy for many skeletal muscle wasting diseases. This review describes the current state of hPSCs towards recapitulating human myogenesis ex vivo, considerations of stem cell and progenitor cell state as well as function for future use of hPSC-derived muscle cells in regenerative medicine.
人类多能干细胞（hPSCs）为发育性肌发生、疾病建模和治疗药物开发提供了人类模型。hPSCs 分化为肌肉干细胞有可能为许多骨骼肌消耗性疾病提供基于细胞的治疗方法。本文综述了 hPSCs 目前在体外重现人类肌发生的情况，讨论了干细胞和祖细胞状态以及未来使用 hPSC 衍生的肌肉细胞进行再生医学的考虑因素。
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