NeuroAllergy Research Laboratory, School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia.
Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia.
Int J Mol Sci. 2021 Dec 20;22(24):13655. doi: 10.3390/ijms222413655.
The IL-4 and IL-13 cytokine pathways play integral roles in stimulating IgE inflammation, with the IL-4 cytokine being a major cytokine in the etiology of thunderstorm asthma, atopic dermatitis, and allergic rhinitis. The increasing prevalence of thunderstorm asthma in the younger population and the lessening efficacy of corticosteroids and other anti-inflammatories has created a need for more effective pharmaceuticals. This review summarizes the IL-4 and IL-13 pathways while highlighting and discussing the current pathway inhibitors aimed at treating thunderstorm asthma and atopic dermatitis, as well as the potential efficacy of peptide therapeutics in this field.
IL-4 和 IL-13 细胞因子途径在刺激 IgE 炎症中发挥着重要作用，其中 IL-4 细胞因子是雷暴性哮喘、特应性皮炎和过敏性鼻炎发病机制中的主要细胞因子。雷暴性哮喘在年轻人群中的发病率不断上升，以及皮质类固醇和其他抗炎药的疗效降低，这使得人们需要更有效的药物。本文综述了 IL-4 和 IL-13 途径，同时强调并讨论了目前针对雷暴性哮喘和特应性皮炎的通路抑制剂，以及肽类治疗在这一领域的潜在疗效。
