Reme T X
Pathol Biol (Paris). 1977 Dec;25(10):735-40.
During the growth of spontaneous or chemically-induced tumors in animals, it has been reported that T lymphocytes are present in the spleen and/or the thymus which are able (i) to specifically block tumor rejection by syngeneic immunized animals in in vivo transfer experiments, and (ii) to specifically inhibit the in vitro cell-mediated immune reactions. The relationship between both types of suppressor cells is unclear. On the other hand, mitogen insensitive cells, acting in vitro in a non specific way on normal cell mitosis and cell-mediated cytotoxicity induction, and having macrophage characteristics, are described in viral and non viral tumor bearing hosts as well as in non tumoral animals after hematopoietic hypoplasia. The various suppressor cells types and their possible mechanisms of action are discussed along with soluble factors when present in experimental tumor systems, but the role of these cells in tumor pathogenesis is not yet clear.
在动物自发性肿瘤或化学诱导肿瘤的生长过程中，据报道，T淋巴细胞存在于脾脏和/或胸腺中，它们能够：（i）在体内转移实验中特异性阻断同基因免疫动物的肿瘤排斥反应；（ii）特异性抑制体外细胞介导的免疫反应。这两种抑制细胞之间的关系尚不清楚。另一方面，在病毒和非病毒肿瘤宿主以及造血功能减退后的非肿瘤动物中，均有关于有丝分裂原不敏感细胞的描述，这些细胞以非特异性方式在体外作用于正常细胞的有丝分裂和细胞介导的细胞毒性诱导，并且具有巨噬细胞特征。当实验肿瘤系统中存在各种抑制细胞类型及其可能的作用机制以及可溶性因子时，会对它们进行讨论，但这些细胞在肿瘤发病机制中的作用尚不清楚。
