Department of General Internal Medicine/Cardiology, Marienhof Hospital, Rudolf-Virchow-Str. 7-9, 56073 Koblenz, Germany.
Cologne Center for Prevention in Childhood and Youth/Heart Center Cologne, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Int J Environ Res Public Health. 2021 Dec 14;18(24):13160. doi: 10.3390/ijerph182413160.
Physical activity (PA) during pregnancy is beneficial for mother and child. Little is known regarding the effects of PA on specific adipokines/myokines and their impact during pregnancy. This study investigates the correlation between PA during late pregnancy, body composition, and maternal levels of leptin, IL-6, and TNF-α at delivery. In a cross-sectional study of 91 pregnant participants (mean age 33.9 ± 4.6 years) without gestational diabetes mellitus or preeclampsia, anthropometric data and blood samples were taken at delivery. PA during the third trimester was measured via the Pregnancy Physical Activity Questionnaire. Activities were ranked by intensity: sedentary (<1.5 metabolic equivalent (METs)), light (1.5-3.0 METs), moderate (3.0-6.0 METs), and vigorous activity (>6.0 METs). Leptin at delivery correlated positively with body composition and negatively with light PA intensity. Sedentary behaviour showed a positive correlation with IL-6 levels at delivery. Moderate activity during the last trimester, sedentary activity levels, and body composition had the greatest influence on maternal IL-6 at delivery. Completed weeks of pregnancy, moderate and light PA, and sedentary activity had the greatest influence on maternal TNF-α at delivery. PA during late pregnancy potentially affects circulating (adipo-)/myokines. Further studies are needed to examine causal relationships and the impact on maternal and new-born health.
孕期身体活动（PA）对母婴均有益。然而，关于 PA 对特定脂肪因子/肌因子的影响及其在孕期的作用知之甚少。本研究旨在调查孕期晚期 PA 与身体成分，以及分娩时母体内瘦素、IL-6 和 TNF-α水平之间的相关性。在一项横断面研究中，共纳入 91 名无妊娠期糖尿病或子痫前期的孕妇（平均年龄 33.9 ± 4.6 岁），在分娩时采集其人体测量学数据和血样。通过孕期身体活动问卷（Pregnancy Physical Activity Questionnaire）评估孕妇在孕晚期的身体活动情况。活动强度分为：久坐（<1.5 代谢当量（METs））、轻体力活动（1.5-3.0 METs）、中强度体力活动（3.0-6.0 METs）和高强度体力活动（>6.0 METs）。分娩时瘦素与身体成分呈正相关，与轻体力活动强度呈负相关。久坐行为与分娩时 IL-6 水平呈正相关。最后三个月的中强度体力活动、久坐行为和身体成分对产妇分娩时的 IL-6 水平影响最大。孕期周数、中强度和轻强度体力活动以及久坐行为对产妇分娩时 TNF-α水平的影响最大。孕期晚期的身体活动可能会影响循环（脂肪/肌）因子。需要进一步的研究来探讨因果关系及其对母婴健康的影响。
