Institute of Environmental Systems Biology, Dalian Maritime University, Dalian 116023, China.
Int J Environ Res Public Health. 2021 Dec 14;18(24):13163. doi: 10.3390/ijerph182413163.
Motion sickness is a common central nervous system response, the primary sign of which is vomiting. Its susceptibility varies between individuals. To find predictive factors, we investigated the association of ADRA2A rs1800544 and HTR3B rs3758987 with motion sickness susceptibility and examined their mRNA changes during actual voyages. A total of 315 healthy college students were enrolled for SNP genotyping by the PCR-RFLP method. Blood samples were collected from another 42 subjects during two separate voyages to detect their mRNA expression changes at three time points. The frequency of the rs1800544 GG genotype in the susceptibility group was significantly higher (52.26%), and allele G increased the risk of motion sickness (OR = 1.585, 95% CI = 1.136-2.208). In the logistic regression model, the rs3758987 CC+TC genotype and rs1800544 GG genotype increased the risk of motion sickness-induced vomiting (OR = 2.105, 95% CI = 1.112-3.984; OR = 1.992, 95% CI = 1.114-3.571). The ADRA2A mRNA baseline was lower in the GG carriers and the HTR3B mRNA baseline was lower in the TC/CC carriers before sailing, then increased significantly within 24 h and then decreased after a long-term voyage. People carrying the rs1800544 GG genotype seem more susceptible to motion sickness. In combination with the incidence of vomiting during the actual-voyage experiments, our results indicate the involvement of rs1800544 and rs3758987 in motion sickness-induced vomiting.
晕动病是一种常见的中枢神经系统反应，主要症状为呕吐。其易感性因人而异。为了寻找预测因素，我们研究了 ADRA2A rs1800544 和 HTR3B rs3758987 与晕动病易感性的关系，并在实际航行中检查了它们的 mRNA 变化。共招募了 315 名健康大学生，通过 PCR-RFLP 方法进行 SNP 基因分型。在两次不同的航行中，从另外 42 名受试者中采集血样，以检测三个时间点的 mRNA 表达变化。易感性组 rs1800544 GG 基因型的频率明显较高（52.26%），等位基因 G 增加了晕动病的风险（OR=1.585，95%CI=1.136-2.208）。在逻辑回归模型中，rs3758987 CC+TC 基因型和 rs1800544 GG 基因型增加了晕动病引起的呕吐的风险（OR=2.105，95%CI=1.112-3.984；OR=1.992，95%CI=1.114-3.571）。在航行前，ADRA2A mRNA 基线在 GG 携带者中较低，HTR3B mRNA 基线在 TC/CC 携带者中较低，然后在 24 小时内显著增加，然后在长途航行后降低。携带 rs1800544 GG 基因型的人似乎更容易患晕动病。结合实际航行实验中呕吐的发生率，我们的结果表明 rs1800544 和 rs3758987 参与了晕动病引起的呕吐。
