Fosse E, Mollnes T E, Ingvaldsen B
J Thorac Cardiovasc Surg. 1987 Jun;93(6):860-6.
Plasma concentrations of the complement products C3dg and the terminal complement complex, as well as the number of granulocytes (polymorphonuclear neutrophils), were assessed in patients undergoing aorta-coronary bypass with extracorporeal circulation, abdominal aneurysmectomy with implantation of an aortic graft, or thoracotomy without the introduction of synthetic material into the circulation. The concentration of terminal complement complex increased significantly only in the group undergoing extracorporeal circulation, with a corresponding drop in the number of granulocytes. In contrast, the C3dg concentration increased during both extracorporeal circulation and abdominal aneurysmectomy, which indicates that other factors than extracorporeal circulation may affect C3 activation during major operations. In the thoracotomy group, where the most pronounced increase in granulocytes was found, no complement activation was recorded. It is concluded that extracorporeal circulation activates the terminal pathway of complement and that assays detecting activation of both the initial and the terminal parts should be included when the pathophysiology of complement is examined during major operations and extracorporeal circulation.
对接受体外循环下主动脉冠状动脉搭桥术、植入主动脉移植物的腹主动脉瘤切除术或未向循环系统中引入合成材料的开胸手术的患者，评估其补体产物C3dg和终末补体复合物的血浆浓度，以及粒细胞（多形核中性粒细胞）数量。仅在接受体外循环的组中，终末补体复合物浓度显著升高，同时粒细胞数量相应下降。相比之下，体外循环和腹主动脉瘤切除术期间C3dg浓度均升高，这表明除体外循环外的其他因素可能在大手术期间影响C3激活。在粒细胞增加最为明显的开胸手术组中，未记录到补体激活。得出的结论是，体外循环激活补体的终末途径，并且在大手术和体外循环期间检查补体的病理生理学时，应包括检测补体初始部分和终末部分激活的检测方法。
