Kerns J M, Pavkovic I M, Fakhouri A J, Wickersham K L, Freeman J A
J Neurosci Methods. 1987 Mar;19(3):217-23. doi: 10.1016/s0165-0270(87)80005-5.
Several studies have shown that nerve fibers grow preferentially toward the cathode when placed in an electrical field. To study the effects of electrical stimulation on in vivo nerve regeneration, an inexpensive implantable current source has been developed which is able to reliably deliver a minute DC current (0.57 microA) via wick electrodes. The current density was measured directly with a vibrating probe and compared to the delivered current. The mean current density along the normal unoperated rat sciatic nerve was 0.19 microA/cm2, while the value along the nerve near the wick electrodes positioned 15 mm apart with an active in vivo implant was 23.39 microA/cm2. This application promises to provide a potentially useful means of enhancing nerve regeneration clinically.
多项研究表明，将神经纤维置于电场中时，它们会优先向阴极生长。为了研究电刺激对体内神经再生的影响，已开发出一种价格低廉的植入式电流源，它能够通过灯芯电极可靠地输送微小的直流电流（0.57微安）。用振动探针直接测量电流密度，并与输送的电流进行比较。正常未手术大鼠坐骨神经沿线的平均电流密度为0.19微安/平方厘米，而在体内植入活性装置、相距15毫米的灯芯电极附近神经沿线的电流密度值为23.39微安/平方厘米。该应用有望为临床上增强神经再生提供一种潜在有用的方法。
