Ramli Danial, Aziz Izzuddin, Mohamad Masro, Abdulahi Dauda, Sanusi Junedah
Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Cyberjaya University College of Medical Sciences (CUCMS), Cyberjaya, Selangor, Malaysia.
Evid Based Complement Alternat Med. 2017;2017:3476407. doi: 10.1155/2017/3476407. Epub 2017 May 23.
Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. As evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid, studies have shown the potential role of EPO in myelination. Seventy-two healthy adult Sprague-Dawley rats were classified into three groups: normal group, control group, and experimental group. The result indicates that there was significant difference in toe-spreading reflex between the normal and the control groups (1.9 ± 0.031, < 0.05) and the normal and the EPO groups (0.4 ± 0.031, < 0.05) and significant difference between EPO and the control groups (1.5 ± 0.031, < 0.05). Regeneration of axons and myelin in nerve fibre in the EPO-treated group developed better and faster than in the control group. In the control group, the shape of the axon was irregular with a thinner myelin sheath. In the experimental group, the shape of the axons, the thickness of the myelin sheath, and the diameter of the axons were almost the same as in the normal group. In conclusion, EPO supplementation may be beneficial as a therapeutic option for disturbances of nerve interaction.
神经挤压伤是常用于轴突断裂以研究周围神经再生的模型。由于月见草油（EPO）富含ω-6必需脂肪酸成分和γ-亚麻酸，研究表明EPO在髓鞘形成中具有潜在作用。将72只健康成年Sprague-Dawley大鼠分为三组：正常组、对照组和实验组。结果表明，正常组与对照组之间（1.9±0.031，<0.05）以及正常组与EPO组之间（0.4±0.031，<0.05）的趾展反射存在显著差异，EPO组与对照组之间也存在显著差异（1.5±0.031，<0.05）。EPO治疗组神经纤维中轴突和髓鞘的再生比对照组更好、更快。在对照组中，轴突形状不规则，髓鞘较薄。在实验组中，轴突形状、髓鞘厚度和轴突直径与正常组几乎相同。总之，补充EPO作为神经相互作用紊乱的治疗选择可能有益。
