无痕切除插入序列可恢复鲍曼不动杆菌的荚膜生成和毒力。
Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.
机构信息
Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, Brussels, Belgium.
Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
出版信息
ISME J. 2022 May;16(5):1473-1477. doi: 10.1038/s41396-021-01179-3. Epub 2021 Dec 23.
We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
我们发现了一种新的机制，介导世界卫生组织和疾病预防控制中心优先关注的 ESKAPE 病原体鲍曼不动杆菌的荚膜产生和毒力。在应激条件下，无荚膜和无毒力的细菌可以通过无痕切除 ISAba13 插入序列，回复为有荚膜和有毒力的状态。回复事件完全恢复了荚膜的产生和体内的毒力。这增加了我们对鲍曼不动杆菌基因组动态、荚膜产生、毒力和耐药性调节的认识。
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