Hu Yi, Xie Xiaohong, Yang Lingchen, Wang Aibing
Laboratory of Animal Disease Prevention and Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Front Microbiol. 2021 Dec 7;12:762358. doi: 10.3389/fmicb.2021.762358. eCollection 2021.
Porcine epidemic diarrhea virus (PEDV), a coronavirus pathogen of the pig intestinal tract, can cause fatal watery diarrhea in piglets, thereby causing huge economic losses to swine industries around the world. The pathogenesis of PEDV has intensively been studied; however, the viral proteins of PEDV and the host factors in target cells, as well as their interactions, which are the foundation of the molecular mechanisms of viral infection, remain to be summarized and updated. PEDV has multiple important structural and functional proteins, which play various roles in the process of virus infection. Among them, the S and N proteins play vital roles in biological processes related to PEDV survival interacting with the host cell proteins. Meanwhile, a number of host factors including receptors are required for the infection of PEDV interacting with the viral proteins, thereby affecting the reproduction of PEDV and contributing to its life cycle. In this review, we provide an updated understanding of viral proteins and host factors, as well as their interactions in terms of PEDV infection. Additionally, the effects of cellular factors, events, and signaling pathways on PEDV infection are also discussed. Thus, these comprehensive and profound insights should facilitate for the further investigations, control, and prevention of PEDV infection.
猪流行性腹泻病毒（PEDV）是一种猪肠道冠状病毒病原体，可导致仔猪致命性水样腹泻，从而给全球养猪业造成巨大经济损失。PEDV的发病机制已得到深入研究；然而，PEDV的病毒蛋白、靶细胞中的宿主因子及其相互作用，作为病毒感染分子机制的基础，仍有待总结和更新。PEDV有多种重要的结构和功能蛋白，它们在病毒感染过程中发挥着各种作用。其中，S蛋白和N蛋白在与PEDV生存相关的生物学过程中起着至关重要的作用，与宿主细胞蛋白相互作用。同时，包括受体在内的许多宿主因子是PEDV感染所必需的，它们与病毒蛋白相互作用，从而影响PEDV的繁殖并促进其生命周期。在这篇综述中，我们对病毒蛋白和宿主因子及其在PEDV感染方面的相互作用提供了最新的认识。此外，还讨论了细胞因子、事件和信号通路对PEDV感染的影响。因此，这些全面而深刻的见解应有助于进一步研究、控制和预防PEDV感染。
