3'-叠氮-3'-脱氧胸苷和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对正常人造血祖细胞的体外毒性
Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.
作者信息
Sommadossi J P, Carlisle R
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):452-4. doi: 10.1128/AAC.31.3.452.
Abstract
The effects of 3'-azido-3'-deoxythymidine (AZT) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on myeloid and erythroid colony-forming cells were studied by clonogenic assays. Both consistently inhibited granulocyte-macrophage CFU (CFU-GM) and erythroid burst-forming units in a dose-dependent fashion. Concentrations of AZT and 9-(1,3-dihydroxy-2-propoxymethyl)guanine required for 50% inhibition of CFU-GM were, respectively, 0.9 +/- 0.1 and 2.7 +/- 0.5 microM; those required for 90% inhibition were, respectively, 34.0 +/- 2.8 and 35.7 +/- 3.6 microM. Erythroid burst-forming units were less sensitive to high concentrations of AZT than were CFU-GM.
摘要
通过克隆形成试验研究了3'-叠氮-3'-脱氧胸苷（AZT）和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对髓系和红系集落形成细胞的影响。二者均以剂量依赖方式持续抑制粒细胞-巨噬细胞集落形成单位（CFU-GM）和红系爆式集落形成单位。抑制CFU-GM 50%所需的AZT和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤浓度分别为0.9±0.1和2.7±0.5微摩尔；抑制90%所需的浓度分别为34.0±2.8和35.7±3.6微摩尔。红系爆式集落形成单位对高浓度AZT的敏感性低于CFU-GM。
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