[BNT162b2疫苗对医护人员预防新型冠状病毒肺炎的有效性]
[Effectiveness of BNT162b2 vaccine to preventing COVID-19 in healthcare personnel].
作者信息
Chico-Sánchez Pablo, Gras-Valentí Paula, Algado-Sellés Natividad, Merino-Lucas Esperanza, Rodríguez-Díaz Juan Carlos, Ronda-Pérez Elena, Sánchez-Payá José
机构信息
Unidad de Epidemiología, Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España.
Unidad de Enfermedades Infecciosas, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España.
出版信息
Gac Sanit. 2022 Sep-Oct;36(5):484-487. doi: 10.1016/j.gaceta.2021.11.003. Epub 2021 Nov 26.
OBJECTIVE
To assess the effectiveness of the vaccine against SARS-CoV-2 (BNT162b2) in healthcare personnel of a health department.
METHOD
Test-negative case̶control study. Healthcare personnel with suspected COVID-19 and healthcare personnel close contacts of COVID-19 cases were included between January 27th and June 6th, 2021. They were PCR tested for SARS-CoV-2; those with positive PCR were considered cases and those with negative PCR were considered controls. The adjusted vaccine effectiveness (aVE) to prevent COVID-19 cases and their 95% confidence interval (95%CI) were calculated using the formula VE=(1-odds ratio)×100.
RESULTS
624 healthcare personnel were included, of which 43 (6.9%) were considered cases and 581 (93.8%) controls. The aVE of the complete regimen was 96.3% (95%CI: 82.5̶99.2). The aVE of the incomplete pattern was 68.0% (95%CI: 30.0̶85.4).
CONCLUSIONS
The administration of the complete pattern of BNT162b2 vaccine against SARS-CoV-2 is effective for the prevention of cases of COVID-19 in healthcare personnel.
目的
评估针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的疫苗（BNT162b2）在某卫生部门医护人员中的有效性。
方法
检测阴性病例对照研究。纳入2021年1月27日至6月6日期间疑似新型冠状病毒肺炎（COVID-19）的医护人员以及COVID-19病例的医护密切接触者。对他们进行SARS-CoV-2的聚合酶链反应（PCR）检测；PCR结果呈阳性者被视为病例，PCR结果呈阴性者被视为对照。使用公式VE =(1 - 比值比)×100计算预防COVID-19病例的调整后疫苗效力（aVE）及其95%置信区间（95%CI）。
结果
纳入624名医护人员，其中43名（6.9%）被视为病例，581名（93.8%）为对照。完整接种方案的aVE为96.3%（95%CI：82.5 - 99.2）。不完整接种模式的aVE为68.0%（95%CI：30.0 - 85.4）。
结论
接种完整模式的针对SARS-CoV-2的BNT162b2疫苗对预防医护人员中的COVID-19病例有效。
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